- ►diabetesjournals.org M Tritt, E Sgouroudis, E d'Hennezel, A Albanese, CA … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—We show that the cellular frequency of Foxp3 + nT reg cells in primary and secondary
lymphoid tissues is stable and does not decline relative to type 1 diabetes–resistant mice. We
show that thymic and peripheral CD4 + CD25 + T-cells are fully functional in vivo. We also ... Cited by 33 - Related articles - BL Direct - All 5 versions
CA Piccirillo - Am Diabetes Assoc M. Tritt, E. Sgouroudis, E. d'Hennezel, A. Albanese, and CA Piccirillo ... Department of Microbiology
and Immunology, and McGill Center for the Study of Host Resistance. McGill University,
Montreal, QC, Canada, H3A 2B4 ... Running title: Functional loss in CD4 + Foxp3 + Treg ... Related articles
RJ Mellanby, D Thomas, JM Phillips, A Cooke - Immunology, 2007 - pubmedcentral.nih.gov The role of regulatory T cells (Tregs) in maintaining self tolerance has been intensively researched
and there is a growing consensus that a decline in Treg function is an important step towards
the development of autoimmune diseases, including diabetes. Although we show here ... Cited by 27 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org T Brusko, C Wasserfall, K McGrail, R Schatz, HL Viener … - Diabetes, 2007 - Am Diabetes Assoc Regulatory T-cells (Tregs) play a critical role in maintaining dominant peripheral tolerance. Previous
characterizations of Tregs in type 1 diabetes have used antibodies against CD4 and α-chain
of the interleukin-2 receptor complex (CD25). This report extends those investigations by ... Cited by 55 - Related articles - BL Direct - All 5 versions
DC Thomas, RJ Mellanby, JM Phillips, A Cooke - Immunology, 2007 - pubmedcentral.nih.gov The role of regulatory T cells (Treg) in maintaining tolerance to self has been intensively
scrutinized, particularly since the discovery of Foxp3 as a Treg-specific transcription factor. The
BDC2·5NOD transgenic mouse is an excellent model of immunoregulation because it has ... Cited by 7 - Related articles - BL Direct - All 6 versions
TIM TREE, BO ROEP, M PEAKMAN - Annals of the New York Academy of …, 2006 - cat.inist.fr Type 1 diabetes mellitus(T 1 DM) is characterized by a loss of self-tolerance to islet antigens.
In health, immunological tolerance is maintained by multiple central and peripheral mechanisms
including the action of a specialized set of regulatory T cells characterized by expression ... Cited by 20 - Related articles - BL Direct - All 3 versions
S You, M Belghith, S Cobbold, MA Alyanakian, C … - Diabetes, 2005 - Am Diabetes Assoc Diabetogenic T-cells can be detected in pre-diabetic nonobese diabetic (NOD) mice after transfer
in NOD-SCID recipients. Here we demonstrate that 6-week-old pre-diabetic NOD mice, >2 months
before disease onset, already harbor pathogenic T-cells in equal numbers to overtly ... Cited by 97 - Related articles - All 5 versions
- ►rupress.org KV Tarbell, L Petit, X Zuo, P Toy, X Luo, A … - Journal of Experimental …, 2007 - jem.rupress.org Most treatments that prevent autoimmune diabetes in nonobese diabetic (NOD) mice require
intervention at early pathogenic stages, when insulitis is first developing. We tested whether
dendritic cell (DC)–expanded, islet antigen–specific CD4 + CD25 + suppressor T cells ... Cited by 96 - Related articles - BL Direct - All 8 versions
- ►nih.gov Q Tang, JY Adams, C Penaranda, K Melli, E Piaggio, E … - Immunity, 2008 - Elsevier The dynamics of CD4 + effector T cells (Teff cells) and CD4 + Foxp3 + regulatory T cells (Treg
cells) during diabetes progression in nonobese diabetic mice was investigated to determine
whether an imbalance of Treg cells and Teff cells contributes to the development of type 1 ... Cited by 55 - Related articles - All 7 versions
- ►jimmunol.org S Gregori, N Giarratana, S Smiroldo, L … - The Journal of …, 2003 - Am Assoc Immnol In the nonobese diabetic (NOD) mouse, pathogenic and suppressor CD4 + T cells can be distinguished
by the constitutive expression of CD25. In this study, we demonstrate that the progression of
autoimmune diabetes in NOD mice reflects modifications in both T cell subsets. CD4 + ... Cited by 126 - Related articles - BL Direct - All 4 versions
