M McDuffie, NA Maybee, SR Keller, BK … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— 12/15-lipoxygenase (12/15-LO), one of a family of fatty acid
oxidoreductase enzymes, reacts with polyenoic fatty acids to produce
proinflammatory lipids. 12/15-LO is expressed in macrophages and pancreatic ... Cited by 6 - Related articles - BL Direct - All 5 versions
- ►shouxi.net EA Ivakine, SM Mortin-Toth, OM Gulban, A … - Diabetes, 2006 - Am Diabetes Assoc The nonobese diabetic (NOD) mouse recapitulates many aspects of the pathogenesis
of type 1 diabetes in humans, including inheritance as a complex trait. More
than 20 Idd loci have been linked to type 1 diabetes susceptibility in NOD ... Cited by 6 - Related articles - BL Direct - All 5 versions
- ►endojournals.org Y Wen, J Gu, SK Chakrabarti, K Aylor, J … - Endocrinology, 2007 - Endocrine Soc 12/15-lipoxygenase (12/15-LO) enzyme and products have been associated with
inflammation and atherosclerosis. However, the mechanism of effects of the
12/15-LO products has not been fully clarified. To study the role of ... Cited by 14 - Related articles - BL Direct - All 3 versions
JL Nadler - Am Diabetes Assoc Marcia McDuffie, MD; University of Virginia Nelly A. Maybee, MD; University of
Virginia Susanna R. Keller, MD; University of Virginia Brian K. Stevens;
University of Virginia James C. Garmey, MS; University of Virginia Margaret ... Related articles - All 2 versions
[CITATION] Braunwald's Heart Disease: a Textbook of Cardiovascular Medicine. Saunders
- ►ahajournals.org MH Nagelin, S Srinivasan, J Lee, JL Nadler, … - Arteriosclerosis, thrombosis, and vascular biology, 2008 - Am Heart Assoc Methods and Results— 12/15LO was stably overexpressed in J774 macrophages.
12/15LO-overexpressing macrophages had a 30% reduction in HDL-mediated
cholesterol efflux, corresponding with significantly reduced ABCG1 protein ... Cited by 5 - Related articles - All 6 versions
RS Dwarakanath, S Sahar, L Lanting, N … - J Vasc Res, 2008 - content.karger.com Increased expression and activity of 12/15-lipoxygenase (12/15-LO) in vascular
smooth muscle cells (VSMCs) play a key role in the pathogenesis of diabetes and
vascular complications. However, the consequences of 12/15-LO ... Cited by 5 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org MK Middleton, T Rubinstein, E Pure - The Journal of Immunology, 2006 - Am Assoc Immnol IL-12 drives type I immune responses and can mediate chronic inflammation that
leads to host defense as well as disease. Recently, we discovered a novel role
for 12/15-lipoxygenase (12/15-LO) in mediating IL-12p40 expression in ... Cited by 15 - Related articles - BL Direct - All 3 versions
- ►ahajournals.org G Jin, K Arai, Y Murata, S Wang, MF Stins, EH … - Stroke, 2008 - Am Heart Assoc Methods— In cell culture, a human brain microvascular endothelial cell line
was subjected to either hypoxia or H 2 O 2 -induced oxidative stress with or
without lipoxygenase inhibitors. For in vivo studies, mice were subjected ... Cited by 5 - Related articles - All 8 versions
- ►physiology.org Y Wen, J Gu, GE Vandenhoff, X Liu, JL Nadler - American Journal of Physiology- Heart and Circulatory …, 2008 - Am Physiological Soc Monocyte chemoattractant protein (MCP)-1 plays a key role in atherosclerosis and
inflammation associated with visceral adiposity by inducing mononuclear cell
migration. Evidence shows that mouse peritoneal macrophages (MPM) express a ... Cited by 12 - Related articles - BL Direct - All 3 versions
