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Scholar Results 1 - 10 of about 101 related to Wiedmann: Genetic variants within the LPIN1 gene, encoding lipin, are influencing phenotypes.... (0.11 sec) 

Genetic variants within the LPIN1 gene, encoding lipin, are influencing phenotypes …


S Wiedmann, M Fischer, M Koehler, K Neureuther, G … - Diabetes, 2008 - Am Diabetes Assoc
RESEARCH DESIGN AND METHODS— A total of 15 single nucleotide polymorphisms
(SNPs) covering the LPIN1 gene region were genotyped in an age- and sex-stratified sample
of the general population (Monitoring Trends and Determinants on Cardiovascular ...
Cited by 10 - Related articles - BL Direct - All 4 versions

Adipose Tissue Lipin-1 Expression Is Correlated with Peroxisome Proliferator- …

- endojournals.org
J Donkor, LM Sparks, H Xie, SR Smith, K … - Journal of Clinical …, 2008 - Endocrine Soc
Results: In healthy young men, lipin-1 expression was positively correlated with insulin sensitivity
(R 2 = 0.22; P < 0.01), insulin-stimulated respiratory quotient (R 2 = 0.16; P < 0.01), and maximal
oxygen consumption during exercise (R 2 = 0.16; P < 0.01). Lipin-1 mRNA levels were ...
Cited by 8 - Related articles - BL Direct - All 6 versions

Association of Lipin 1 Gene Polymorphisms with Measures of Energy and Glucose …


RJF Loos, T Rankinen, L Pérusse, A Tremblay, JP … - Obesity, 2007 - nature.com
Results: The strongest results were generation-specific. In parents, RMR of the G/G IVS13 +
3333A>G homozygotes was 107 kcal/d higher than in A/A homozygotes and 39 kcal/d higher
than in A/G heterozygotes (p = 0.0003). In offspring, carriers of the C allele of the IVS18 + ...
Cited by 8 - Related articles - All 3 versions

Evaluating the role of LPIN1 variation in insulin resistance, body weight, and …


KA Fawcett, N Grimsey, RJF Loos, E Wheeler, A Daly, … - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE— Loss of lipin 1 activity causes lipodystrophy and insulin resistance in the fld
mouse, and LPIN1 expression and common genetic variation were recently suggested to influence
adiposity and insulin sensitivity in humans. We aimed to conduct a comprehensive ...
Cited by 3 - Related articles - All 6 versions

LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic …


ES Kang, SE Park, SJ Han, SH Kim, CM Nam, CW … - Molecular genetics and …, 2008 - Elsevier
Lipin1 protein, a product of the LPIN1 gene, is required for normal adipose tissue development
and metabolism. Lipin1 deficiency results in immature adipocyte development in cases of mouse
fatty liver dystrophy and human lipodystrophy. Recently, pioglitazone has been reported ...
Cited by 5 - Related articles - All 3 versions

Association of a polymorphism in the lipin 1 gene with systolic blood pressure in …


KL Ong, RYH Leung, LYF Wong, SS Cherny, PC … - American journal of …, 2008 - nature.com
None of the tagging SNPs were found to be associated with hypertension after correcting for
multiple testing, although carriers of the minor allele of rs10520097 had nominally lower odds
for hypertension (P = 0.014). After excluding subjects who were on antihypertensive ...
Cited by 4 - Related articles - All 4 versions

Hepatic lipin 1β expression is diminished in insulin-resistant obese subjects and is …

- angrylapdog.com
MA Croce, JC Eagon, LL LaRiviere, KM … - …, 2007 - diabetes.diabetesjournals.org.p. …
RESULTS— The expression of lipin 1β in liver and adipose tissue was inversely related to
BMI, fasting plasma insulin concentration, and the homeostasis model assessment of insulin
resistance but was significantly increased by marked weight loss and insulin sensitization ...
Cited by 13 - Related articles - BL Direct - All 5 versions

Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood

- nih.gov
A Zeharia, A Shaag, RH Houtkooper, T Hindi, P De … - The American Journal of …, 2008 - Elsevier
Recurrent episodes of life-threatening myoglobinuria in childhood are caused by inborn errors
of glycogenolysis, mitochondrial fatty acid beta-oxidation, and oxidative phosphorylation.
Nonetheless, approximately half of the patients do not suffer from a defect in any of these ...
Cited by 4 - Related articles - All 8 versions

Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate …


K Reue, DN Brindley - The Journal of Lipid Research, 2008 - ASBMB
Phosphatidate phosphatase-1 (PAP1) enzymes have a key role in glycerolipid synthesis through
the conversion of phosphatidate to diacylglycerol, the immediate precursor of triacylglycerol,
phosphatidylcholine, and phosphatidylethanolamine. PAP1 activity in mammals is ...
Cited by 10 - Related articles - All 7 versions

Genetic variants within the LPIN1 gene, encoding lipin, are influencing phenotypes …


DA MD, SH MD, HC MD, BA MD, G Neuherberg - Am Diabetes Assoc
1Clinic for Internal Medicine II, University of Regensburg, Regensburg, Germany 2GSF-National
Research Center for Environment and Health, Institute for Epidemiology, Neuherberg, Germany
3Clinic for Internal Medicine 2, University of Schleswig-Holstein, Lübeck, Germany ...
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