- ►diabetesjournals.org JPH Shield, SE Flanagan, DJ Mackay, LW … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Activating mutations in the KCNJ11 and ABCC8 genes encoding the
Kir6.2 and SUR1 subunits of the pancreatic ATP-sensitive K + channel are the
most common cause of permanent neonatal diabetes. In contrast to KCNJ11, ... Cited by 6 - Related articles - BL Direct - All 5 versions
AI Tarasov, CA Girard, B Larkin, P Tammaro, … - Diabetes Obes Metab, 2007 - interscience.wiley.com Heterozygous activating mutations in Kir6.2 (KCNJ11), the pore-forming subunit
of the adenosine triphosphate (ATP)-sensitive potassium (K ATP ) channel, are a
common cause of neonatal diabetes (ND). We assessed the functional effects ... Cited by 2 - Related articles - All 2 versions
YM Chan, LM Laffel - Pediatric Diabetes, 2007 - interscience.wiley.com Abstract: Initial management of neonatal diabetes mellitus consists of insulin
and adequate calories for growth. Once a genetic diagnosis is made, most
patients with neonatal diabetes caused by mutations in the KCNJ11 gene can ... Cited by 3 - Related articles - BL Direct - All 3 versions
- ►nih.gov H de Wet, MG Rees, K Shimomura, J … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Gain-of-function mutations in the genes encoding the ATP-sensitive potassium (K
ATP ) channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) are a common cause of
neonatal diabetes mellitus. Here we investigate the molecular mechanism by ... Cited by 9 - Related articles - BL Direct - All 7 versions
- ►pedpath.org RM Greer, J Shah, YW Jeske, D Brown, RM … - Pediatric and Developmental Pathology, 2007 - pedpath.org In hyperinsulinism of infancy (HI), unregulated insulin secretion causes
hypoglycemia. Pancreatectomy may be required in severe cases, most of which
result from a defect in the β-cell K ATP channel, encoded by ABCC8 and ... Cited by 4 - Related articles - All 2 versions
K Hussain, SE Flanagan, VV Smith, M Ashworth … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Congenital hyperinsulinism (CHI) may be due to diffuse or focal
pancreatic disease. The diffuse form is associated with an increase in the size
of β-cell nuclei throughout the whole of the pancreas and most commonly ... Cited by 10 - Related articles - BL Direct - All 4 versions
FR Grati, L Turolla, P d'Ajello, A Ruggeri, M … - British Medical Journal, 2007 - jmg.bmj.com Background: The phenotypic variability in Beckwith–Wiedemann syndrome (BWS)
reflects the genetic heterogeneity of the mechanism which by default leads to
the deregulation of genes located at 11p15.5. Genotype–phenotype ... Cited by 6 - Related articles - BL Direct - All 6 versions
J Santiago, M Muszlak, C Samson, E Goulois, … - Archives de pédiatrie, 2008 - Elsevier Le syndrome de Wiedemann-Beckwith (SWB) est un syndrome de croissance excessive
prédisposant, a priori, à la survenue de tumeurs embryonnaires dans les
premières années de vie. Si ce risque est globalement évalué entre 7,5 ... Related articles - All 2 versions
I Rica, C Luzuriaga, G Perezdenanclares, I … - Diabetic Medicine, 2007 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 7 - Related articles - BL Direct - All 4 versions
