V Tolle, MJ Low - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Hyperphagic POMC-deficient mice were more sensitive than wild-type
mice to the anorectic effects of MTII. Hypothalamic melanocortin-3 (MC3)/4-R
mRNAs in POMC-deficient mice were unchanged, suggesting increased receptor ... Cited by 10 - Related articles - BL Direct - All 4 versions
- ►nih.gov O Ilnytska, G Argyropoulos - Cellular and Molecular Life Sciences, 2008 - Springer Abstract. The Agouti-Related Protein (AgRP) is a powerful orexigenic peptide
thatincreases food intake when ubiquitously overexpressed or when adminis- tered
centrally. AgRP-deficiency, on the other hand, leads to increased metabolic ... Cited by 3 - Related articles - All 4 versions
- ►nih.gov M Lee, A Kim, IM Conwell, V Hruby, A … - Peptides, 2008 - Elsevier Hypothalamic POMC neurons regulate energy balance via interactions with brain
melanocortin receptors (MC-Rs). POMC neurons express the MC3-R which can
function as an inhibitory autoreceptor in vitro. We now demonstrate that ... Cited by 5 - Related articles - All 3 versions
S Srinivasan, P Santiago, C Lubrano, C … - PLoS ONE, 2007 - pubmedcentral.nih.gov The molecular and functional diversity of G protein–coupled receptors is
essential to many physiological processes. However, this diversity presents a
significant challenge to understanding the G protein–mediated signaling ... Cited by 7 - Related articles - All 4 versions
A Breit, K Wolff, H Kalwa, H Jarry, T Büch, T … - Journal of Biological Chemistry, 2006 - ASBMB Agouti-related protein (Agrp), one of the two naturally occurring inverse
agonists known to inhibit G protein-coupled receptor activity, regulates energy
expenditure by decreasing basal and blocking agonist-promoted melanocortin ... Cited by 15 - Related articles - All 6 versions
M Chen, A Celik, KE Georgeson, CM Harmon, … - Regulatory peptides, 2006 - Elsevier We have investigated receptor structural components of the melanocortin-4
receptor (MC4R) responsible for ligand-dependent inverse agonism. We utilized
agouti-related protein (AGRP), an inverse agonist which reduces MC4R basal ... Cited by 7 - Related articles - All 3 versions
IS Farooqi, S O'Rahilly - Nature clinical practice. Endocrinology & metabolism, 2008 - ncbi.nlm.nih.gov Obesity is associated with increased morbidity and mortality from cardiovascular
disease, diabetes mellitus and certain cancers. The prevalence of obesity is
increasing rapidly throughout the world and is now recognized as a major ... Cited by 10 - Related articles - All 3 versions
J Moriya, Y Takimoto, K Yoshiuchi, T … - Psychoneuroendocrinology, 2006 - Elsevier Agouti-related protein (AGRP) is the competitive antagonist of alpha-melanocyte
stimulating hormone (α-MSH) located at melanocortin receptors 3 and 4 (MC3R and
MC4R), and also acts as an MC4R inverse agonist. Hypothalamic AGRP controls ... Cited by 7 - Related articles - All 14 versions
- ►nih.gov Q Wu, MP Howell, MA Cowley, RD Palmiter - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences Ablation of inhibitory agouti-related protein (AgRP)-expressing neurons in the
arcuate nucleus that also synthesize γ-amino-butyric acid (GABA) and
neuropeptide Y in adult mice leads to starvation within 1 week. The removal ... Cited by 7 - Related articles - BL Direct - All 8 versions
- ►cjb.net GM Sutton, D Perez-Tilve, R Nogueiras, J … - Journal of Neuroscience, 2008 - neuro.cjb.net Entrainment of anticipatory activity and wakefulness to nutrient availability is
a poorly understood component of energy homeostasis. Restricted feeding (RF)
paradigms with a periodicity of 24 h rapidly induce entrainment of rhythms ... Cited by 9 - Related articles - All 4 versions
