- ►diabetesjournals.org K Morino, S Neschen, S Bilz, S Sono, D … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Tg IRS-1 Ser→Ala mice were protected from fat-induced insulin
resistance, as reflected by lower plasma glucose concentrations during a glucose
tolerance test and increased insulin-stimulated muscle glucose uptake ... Cited by 11 - Related articles - All 4 versions
K Bouzakri, P Ribaux, A Tomas, G Parnaud, … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Protein kinase B/Akt plays a central role in β-cells, but little
is known regarding downstream Akt substrates in these cells. Recently, Rab
GTPase-activating protein AS160, a substrate of Akt, was shown to be ... Cited by 5 - Related articles - BL Direct - All 4 versions
S Boura-Halfon, Y Zick - American Journal of Physiology- Endocrinology And …, 2009 - Am Physiological Soc Insulin signaling at target tissues is essential for growth and development and
for normal homeostasis of glucose, fat, and protein metabolism. Control over
this process is therefore tightly regulated. It can be achieved by a ... Cited by 6 - Related articles - All 3 versions
B Yermen, A Tomas, PA Halban - Diabetes, 2007 - Am Diabetes Assoc We have previously shown that the Ca 2+ -dependent actin-severing protein
gelsolin plays an important role in regulated insulin secretion. The aim of this
study was to determine the role of gelsolin in β-cell survival as it has ... Cited by 7 - Related articles - BL Direct - All 6 versions
- ►shouxi.net Z Yi, P Langlais, EA De Filippis, M Luo, CR … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Research has focused on insulin receptor substrate (IRS)-1 as a
locus for insulin resistance. Tyrosine phosphorylation of IRS-1 initiates
insulin signaling, whereas serine/threonine phosphorylation alters the ... Cited by 7 - Related articles - BL Direct - All 5 versions
DL Eizirik, ML Colli, F Ortis - Nature Reviews Endocrinology, 2009 - phx1.medscape.com Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with a strong
inflammatory component. The latest studies indicate that innate immunity and
inflammatory mediators have a much broader role in T1DM than initially ... Cited by 8 - Related articles - All 8 versions
- ►diabetesjournals.org D Li, X Yin, EJ Zmuda, CC Wolford, X Dong, … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—We used both the gain- and loss-of-function
approaches to test the effects of ATF3 on IRS2 gene expression. We also analyzed
the binding of ATF3 to the IRS2 promoter by chromatin immunoprecipitation ... Cited by 9 - Related articles - BL Direct - All 5 versions
- ►endojournals.org M Luo, P Langlais, Z Yi, N Lefort, EA De … - Endocrinology, 2007 - Endocrine Soc The function of insulin receptor substrate-1 (IRS-1) is regulated by both
tyrosine and serine/threonine phosphorylation. Phosphorylation of some
serine/threonine residues in IRS-1 dampens insulin signaling, whereas ... Cited by 8 - Related articles - BL Direct - All 3 versions
- ►physiology.org H Sharfi, H Eldar-Finkelman - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc Serine phosphorylation of insulin receptor substrate (IRS) proteins is a
potential inhibitory mechanism in insulin signaling. Here we show that IRS-2 is
phosphorylated by glycogen synthase kinase (GSK)-3. Phosphorylation by ... Cited by 8 - Related articles - BL Direct - All 3 versions
M Lawrence, C Shao, L Duan, K McGlynn, … - Acta Physiologica, 2008 - interscience.wiley.com Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) activities are
modulated in a manner that reflects the secretory demand on β cells to
integrate long- and short-term nutrient sensing information. Our studies ... Cited by 11 - Related articles - BL Direct - All 3 versions
