MR Rigby, AM Trexler, TC Pearson, CP Larsen - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Nod.scid recipients of diabetogenic BDC2.5.NOD cells were protected indefinitely
from diabetes by a short course of combined costimulation blockade, despite the continued diabetogenic
potential of their T-cells. The presence of pathogenic T-cells in the absence of disease ... Cited by 1 - Related articles - All 6 versions
- ►diabetesjournals.org [PDF] MR Rigby, AM Trexler, TC Pearson, CP Larsen - Diabetes, 2008 - Am Diabetes Assoc CD28/CD154 blockade prevents autoimmune diabetes by inducing non-deletional tolerance
following effector T cell inhibition and regulatory T cell expansion. ... Mark R. Rigby, MD,
PhD1,2,3 Alison M. Trexler, BA2 Thomas C. Pearson, MD, PhD2,3 Christian P. Larsen, ... Related articles - All 2 versions
S Peng, S Lalani, JW Leavenworth, IC Ho … - European Journal of …, 2007 - interscience.wiley.com The transcription factor c-Maf is critical for IL-4 production and the development of Th2 cells,
which promote humoral immunity and protect against extracellular parasites. Yet, little else is
known of c-Maf function in CD4 cells. Here, we identify a novel role for c-Maf in regulating ... Cited by 5 - Related articles - BL Direct - All 2 versions
- ►jimmunol.org SS Smith, T Patterson, ME Pauza - The Journal of Immunology, 2005 - Am Assoc Immnol Activation of islet-specific T cells plays a significant role in the development of type 1
diabetes. In an effort to control T cell activation, we expressed the inhibitory receptor,
Ly-49A, on islet-specific mouse CD4 cells. Ag-mediated activation of Ly-49A T cells was ... Cited by 5 - Related articles - All 5 versions
- ►highwire.org SML Tamma, SP Balan, KW Chung, S … - Journal of Leukocyte …, 2006 - jleuk.highwire.org Costimulatory signals play an important role in the development of T helper cell type 1 (Th1)
or Th2 type. Little is known about jacalin plus CD28-mediated signaling and cytokine
secretion. In the present study, we analyzed the intracellular signaling events following ... Cited by 6 - Related articles - BL Direct - All 5 versions
- ►jbc.org JE Wood, H Schneider, CE Rudd - Journal of Biological Chemistry, 2006 - ASBMB TcR /CD3 and TcR /CD3-CD28 signaling requires the guanine nucleotide exchange factor
(GEF) Vav-1 as well as the activation of phosphatidylinositol 3-kinase, protein kinase B
(PKB/AKT), and its inactivation of glycogen synthase kinase-3 (GSK-3). Whether these ... Cited by 8 - Related articles - All 8 versions
H Tsukamoto, A Irie, YZ Chen, K Takeshita, … - European journal of … - interscience.wiley.com The interactions between peptide/MHC complexes and their cognate TCR are essential for various
T cell responses. However, the relationship between the avidity of TCR ligand and the subsequent
intracellular signaling through the TCR is still unclear. To investigate the effects of TCR ... Cited by 3 - Related articles - BL Direct - All 4 versions
JW Leavenworth, ME Pauza - Cellular Immunology, 2009 - Elsevier Islet specific CD4 cells expressing inhibitory receptors may be a useful therapeutic tool for treating
type 1 diabetes (T1D). Engagement of transgenic Ly49A inhibits CD4 cell activation and delays
onset of T1D in mice. However, in vitro studies suggest the inhibitory effect of Ly49A is ... Related articles
- ►oxfordjournals.org K Eshima, C Mora, FS Wong, EA Green, IS … - International …, 2003 - Jpn Soc Immunol Although the critical requirement of CD4 T cells in type I (insulin-dependent) diabetes mellitus
(T1DM) has been well documented, information on the exact role(s) of CD4 T cells in T1DM development
is still limited. Here, utilizing non-obese diabetic (NOD) mice deficient for CD154 ... Cited by 10 - Related articles - BL Direct - All 4 versions
JA Bluestone, H Boehmer - Seminars in Immunology, 2006 - Elsevier This issue of Seminars in Immunology considers possible clinical applications of regulatory T
cells based on a number of pre-clinical rodent models of disease and some clinical studies. There
are many “types” of regulatory T cells. The majority of the manuscripts focus on Foxp3- ... Cited by 10 - Related articles
