JM Wenzlau, Y Liu, L Yu, O Moua, KT Fowler, S … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Sera from 224 subjects (53%) were reactive to Arg 325 probes, from 185 (44%)
to Trp 325 probes, and from 142 (34%) to Gln 325 probes. Sixty subjects reacted only with Arg
325 constructs, 31 with Trp 325 only, and 1 with Gln 325 only. The restriction to either Arg ... Cited by 12 - Related articles - All 4 versions
H Gohlke, U Ferrari, K Koczwara, E … - The Review of …, 2008 - pubmedcentral.nih.gov It was recently shown that the major allele of the SLC30A8 (zinc transporter 8, ZnT8) single nucleotide
polymorphism (SNP) rs13266634 was associated with type 2 diabetes and with reduced insulin
secretion in non-diabetic relatives. Because of its role in beta-cell function, we ... Cited by 11 - Related articles - All 4 versions
- ►nagasaki-u.ac.jp [PDF] E Kawasaki, M Uga, K Nakamura, G Kuriya, T Satoh, K … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis We analysed the association between humoral autoreactivity to zinc
transporter-8 (ZnT8) and the SLC30A8 rs13266634 polymorphism (Arg325Trp), which is located
at the most distal loop in the ZnT8 protein. Methods Autoantibodies to ZnT8 were ... Cited by 9 - Related articles - All 3 versions
JM Wenzlau, O Moua, SA Sarkar, L Yu, M Rewers, GS … - System, 1927 - interscience.wiley.com Type 1A diabetes (T1D) results from autoimmunity targeted at a limited number of molecules
that are expressed in the pancreatic β cell. Putative novel autoantigen candidates were identified
from microarray expression profiling of human and rodent islet cells. The highest ranking ... Cited by 6 - Related articles - All 5 versions
TW Boesgaard, J Žilinskaitė, M Vänttinen, M Laakso, … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis A recent genome-wide association study identified the SLC30A8 rs13266634
polymorphism encoding an Arg325Trp polymorphism in the zinc transporter protein member
8 (ZnT-8) to be associated with type 2 diabetes. Here, ... Keywords Beta cell dysfunction . ... Cited by 20 - Related articles - BL Direct - All 3 versions
JM Wenzlau, O Moua, Y Liu, GS Eisenbarth, JC Hutton, … - System, 1927 - interscience.wiley.com The human zinc transporter Slc30A8 (ZnT8) is a major target of humoral autoimmunity in human
type 1A diabetes. However, despite extensive conservation, the majority of human autoimmune
sera fail to recognize the murine ortholog. Moreover, Slc30A8 appears not to be a ... Cited by 4 - Related articles - All 5 versions
C Brorsson, R Bergholdt, M Sjögren, S Eising, KM … - Molecular Genetics and …, 2008 - Elsevier Common complex diseases like type 1 diabetes (T1D) are believed to result from interactions
between multiple risk-conferring genes and environmental factors. The understanding of the
underlying factors of diabetes development is important for predicting who is at risk of ... Cited by 6 - Related articles - All 2 versions
HQ Qu, SFA Grant, JP Bradfield, C Kim, E Frackelton, H … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—Two European population samples were studied: 1)
one case-control cohort of 514 type 1 diabetic subjects and 2,027 control subjects and 2) one
family cohort of 483 complete type 1 diabetic case-parent trios (total 997 affected). A total ... Cited by 12 - Related articles - All 5 versions
JK Hertel, S Johansson, H Raeder, K Midthjell, V … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis Recent genome-wide association studies performed in selected patients
and control participants have provided strong support for several new type 2 diabetes susceptibility
loci. To get a better estimation of the true risk conferred by these novel loci, we tested a ... Cited by 13 - Related articles - BL Direct - All 2 versions
AV Gyulkhandanyan, H Lu, SC Lee, A … - Journal of Biological …, 2008 - ASBMB During insulin secretion, pancreatic α-cells are exposed to Zn 2+ released from insulin-containing
secretory granules. Although maintenance of Zn 2+ homeostasis is critical for cell survival and
glucagon secretion, very little is known about Zn 2+ -transporting pathways and the ... Cited by 13 - Related articles - All 4 versions
