Y Jiang, W Nishimura, D Devor-Henneman, D Kusewitt, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Selective deletion of survivin in pancreatic endocrine cells in the mouse had no
discernible effects during embryogenesis but was associated with striking decreases in β-cell
number after birth, leading to hyperglycemia and early-onset diabetes by 4 weeks of age. ... Cited by 4 - Related articles - All 5 versions
M Gannon, E Tweedie Ables, L Crawford, D Lowe, MF … - Developmental biology, 2008 - Elsevier The pdx1 gene is essential for pancreatic organogenesis in humans and mice; pdx1 mutations
have been identified in human diabetic patients. Specific inactivation of pdx1 in adult β cells
revealed that this gene is required for maintenance of mature β cell function. In the ... Cited by 10 - Related articles - All 4 versions
M Kapasa, I Serafimidis, A Gavalas, S Kossida - Genomics, 2008 - Elsevier WISP1 and CTGF are members of the CCN family of growth factors encoding extracellular matrix
proteins participating in several developmental and tumorigenic processes. Both are induced
by the WNT signaling pathway, and microarray data suggest that expression of WISP1 ... Cited by 1 - Related articles - All 3 versions
A Radziszewska, SA Schroer, D Choi, P Tajmir, N … - Journal of Biological …, 2009 - ASBMB Progressive β-cell insufficiency is a hallmark of both type 1 and 2 diabetes. Although the instigating
factors that lead to β-cell failure in these two types of diabetes may differ, the apoptotic machinery
that results in β-cell apoptosis is likely common. In type 2 diabetes, the decrease in ... Cited by 1 - Related articles - All 3 versions
LW Crawford, ET Ables, YA Oh, B Boone, S Levy, M … - PLoS One, 2008 - pubmedcentral.nih.gov In the past decade, several transcription factors critical for pancreas organogenesis have been
identified. Despite this success, many of the factors necessary for proper islet morphogenesis
and function remain uncharacterized. Previous studies have shown that transgenic over- ... Cited by 2 - Related articles - All 5 versions
- ►diabetesjournals.org A Fukuda, Y Kawaguchi, K Furuyama, S Kodama, M … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Most pancreatic endocrine cells derive from Ptf1a-expressing progenitor cells.
In humans, nonsense mutations in Ptf1a have recently been identified as a cause of permanent
neonatal diabetes associated with pancreatic agenesis. The death of Ptf1a-null mice ... Cited by 2 - Related articles - All 4 versions
LA Crawford, MA Guney, YA Oh, RA DeYoung, … - Molecular …, 2009 - Endocrine Soc The factors necessary for normal pancreatic islet morphogenesis have not been well
characterized. Here we report that connective tissue growth factor (CTGF) is involved in the establishment
of normal islet endocrine cell ratio and architecture. CTGF is a secreted protein known to ... Cited by 2 - Related articles - All 3 versions
E Tweedie, I Artner, L Crawford, G Poffenberger, B … - Diabetes, 2006 - Am Diabetes Assoc The Onecut homeodomain transcription factor hepatic nuclear factor 6 (Hnf6) is necessary for
proper development of islet β-cells. Hnf6 is initially expressed throughout the pancreatic epithelium
but is downregulated in endocrine cells at late gestation and is not expressed in postnatal ... Cited by 4 - Related articles - BL Direct - All 6 versions
Y Wang, H Feng, C Bi, L Zhu, JW Pollard, B Chen - FEBS letters, 2007 - Elsevier We report that glycogen synthase kinase (GSK)-3β is phosphorylated at ser9 and inactivated
in uterine epithelial cells from E 2 -treated cyclin D1 null mutant mice. Simultaneous administration
of P 4 together with E 2 blocked this effect. Pharmacological inhibition of GSK-3β activity ... Cited by 4 - Related articles - All 6 versions
- ►diabetesjournals.org ZV Wang, J Mu, TD Schraw, L Gautron, JK Elmquist, BB … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Islet transplantations have been performed clinically, but their practical applications
are limited. An extensive effort has been made toward the identification of pancreatic β-cell stem
cells that has yielded many insights to date, yet targeted reconstitution of β-cell mass ... Cited by 4 - Related articles - All 4 versions
