WPS Wong, DW Scott, CL Chuang, S Zhang, H Liu, A … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Diabetes occurred in hemizygous human amylin transgenic mice from 6 weeks after
birth. Glucose tolerance was impaired during the mid- and end-diabetic phases, in which progressive
β-cell loss paralleled decreasing pancreatic and plasma insulin and amylin. Peripheral ... Cited by 2 - Related articles - All 4 versions
Z Liu, JG Xu, H Zhang, YJ Fang, YA Mei - Journal of cellular physiology - interscience.wiley.com Ceramides are novel second messengers that may mediate signaling leading to apoptosis and
the regulation of cell cycle progression. Moreover, ceramide analogs have been reported to directly
modulate K + and Ca 2+ channels in different cell types. In this report, the effect of C 6 - ... Cited by 3 - Related articles - BL Direct - All 4 versions
S Casas, A Novials, F Reimann, R Gomis, FM Gribble - Diabetologia, 2008 - Springer Abstract Aims/hypothesis To investigate the mechanism by which human islet amyloid polypeptide
(hIAPP) fibril formation results in calcium influx across the plasma membrane of pancreatic beta
cells, and its association with apoptosis. Methods Cytoplasmic intracellular calcium ... Cited by 3 - Related articles - All 3 versions
- ►oxfordjournals.org BW Koo, JA Hebda, AD Miranker - Protein Engineering Design and …, 2008 - Oxford Univ Press Amyloid fibers are aggregated, yet highly ordered, β-sheet-rich assemblies of misfolded
proteins. Order is established in such systems following profiles indicative of nucleation-dependent
assembly. Nucleation dependence suggests that specific interactions, such as long-range ... Cited by 3 - Related articles - BL Direct - All 4 versions
- ►physiology.org C Huang, L Haataja, T Gurlo, AE Butler, X … - American Journal of …, 2007 - Am Physiological Soc The islet in type 2 diabetes is characterized by an 60% β-cell deficit, increased β-cell
apoptosis, and islet amyloid derived from islet amyloid polypeptide (IAPP). Human IAPP
(hIAPP) but not rodent IAPP (rIAPP) forms toxic oligomers and amyloid fibrils in an ... Cited by 10 - Related articles - BL Direct - All 3 versions
S Zhang, H Liu, J Liu, CA Tse, M Dragunow, GJ … - FEBS …, 2006 - interscience.wiley.com Amylin-mediated islet β-cell death is implicated in diabetogenesis. We previously reported that
fibrillogenic human amylin (hA) evokes β-cell apoptosis through linked activation of Jun N-terminal
kinase 1 (JNK 1) and a caspase cascade. Here we show that p38 kinase [p38 mitogen- ... Cited by 14 - Related articles - BL Direct - All 4 versions
HY Park, JI Park, DW Baek, SY Lee, MJ Lee, JO Jin, … - International …, 2006 - Elsevier This study examined the effect of amyloid β peptide (Aβ) and the secretase inhibitors of amyloid
precursor proteins (APP) on the spontaneous apoptosis of neutrophils. Aβ(1–40) decreased
the apoptotic rate of neutrophils. The delayed apoptosis by Aβ was not blocked by ... Cited by 6 - Related articles - All 4 versions
C Ramström, H Chapman, E Ekokoski, RK Tuominen, … - Cellular signalling, 2004 - Elsevier Tumor necrosis factor alpha (TNFα) alters the electrophysiological properties of many cell
types. In thyroid cells however, the effects have not yet been elucidated. Here, we report the effect
of TNFα and its second messenger ceramide on the resting membrane potential (RMP) of ... Cited by 5 - Related articles - All 4 versions
E Karlsson, S Sandler - Diabetologia, 2001 - Springer Aims/hypothesis. We aimed to clarify the role of islet amyloid polypeptide, which is expressed
at early em- bryonic onset, in the proliferation and cell death of neonatal islet cells. Methods.
Fetal islets were prepared from pregnant rats on gestational day 21. Islets were cultured ... Cited by 5 - Related articles - BL Direct - All 4 versions
