NM Fiaschi-Taesch, DM Berman, BM Sicari, KK Takane … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Baseline glucose values were 454.7 ± 11.3 mg/dl (n = 7). Transplant of 500 NHP
islet equivalents (IE) had only a marginal effect on blood glucose (369.1 ± 9.7 mg/dl, n = 5). In
striking contrast, 500 NHP IE transduced with Ad.mHGF promptly and continuously ... Cited by 2 - Related articles - All 5 versions
- ►nih.gov JC Schisler, PT Fueger, DA Babu, HE … - Molecular and cellular …, 2008 - Am Soc Microbiol The homeodomain transcription factor Nkx6.1 plays an important role in pancreatic islet β-cell
development, but its effects on adult β-cell function, survival, and proliferation are not well
understood. In the present study, we demonstrated that treatment of primary rat pancreatic ... Cited by 4 - Related articles - BL Direct - All 7 versions
[CITATION] Adenovirus-mediated hepatocyte growth factor transfer to murine islets improves …
RC Vasavada, L Wang, Y Fujinaka, KK Takane, TC … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE— Diabetes results from a deficiency of functional β-cells. Previous studies have
identified hepatocyte growth factor (HGF) and parathyroid hormone–related protein (PTHrP)
as two potent β-cell mitogens. The objective of this study is to determine 1) whether HGF ... Cited by 7 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org P Rao, J Roccisana, KK Takane, R Bottino, A Zhao, M … - Diabetes, 2005 - Am Diabetes Assoc Akt is an important intracellular mediator of β-cell growth and survival in rodents. However, whether
constitutive activation of Akt in human β-cells enhances the survival and function of transplanted
islets is unknown. In the current study, we examined the efficacy of constitutive activation ... Cited by 19 - Related articles - All 6 versions
[CITATION] Hepatocyte growth factor gene therapy for pancreatic islets: reducing the minimal …
M Icyuz, SMJ Bryant, HK Fortinberry, K Molakandov, … - Transplantation, 2009 - journals.lww.com Transplantation. Wolters Kluwer Health Logo. All Issues. ... Related articles - All 2 versions
A Plesner, P Liston, R Tan, RG Korneluk, CB Verchere - Diabetes, 2005 - Am Diabetes Assoc Allotransplantation of pancreatic islets represents a promising approach to treat type 1
diabetes. Destruction of β-cells in islet allografts involves multiple immune mechanisms that lead
to activation of caspases and apoptotic cell death. The X-linked inhibitor of apoptosis ... Cited by 15 - Related articles - BL Direct - All 6 versions
M Nakano, Y Yasunami - Transplantation, 2001 - journals.lww.com Hepatocyte growth factor (HGF) has been reported to induce proliferation of human fetal β cells
as well as insulinotropic activity in vitro (1-4) . The role of HGF and its receptor/c-met in normal
pancreatic development and maturation in vivo has also been reported (5) . These ... Related articles - BL Direct
TR Flotte, P Ng, DE Dylla, PB McCray, G Wang, JK … - Molecular Therapy, 2007 - nature.com Gene and cell-based therapies are considered to be potentially powerful new approaches for
the management of cystic fibrosis (CF) lung disease. Despite tremendous efforts that have been
made, especially in studies to understand the obstacles to gene delivery, major ... Cited by 17 - Related articles - All 3 versions
