H Bugger, S Boudina, XX Hu, J Tuinei, VG Zaha, HA … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— Resting cardiac function was normal in Akita mice, and myocardial insulin sensitivity
was preserved. Although Akita hearts oxidized more fatty acids, myocardial O 2 consumption
was not increased, and cardiac efficiency was not reduced. ADP-stimulated mitochondrial ... Cited by 9 - Related articles - All 4 versions
JA Herlein, BD Fink, Y O'Malley, WI Sivitz - Endocrinology, 2009 - Endocrine Soc Mitochondrial reactive oxygen species have been implicated in both diabetic complications and
the progression of the underlying diabetic state. However, it is not clear whether mitochondria
of diabetic origin are intrinsically altered to generate excess reactive oxygen species ... Cited by 5 - Related articles - All 3 versions
- ►physiology.org BD Fink, JA Herlein, K Almind, S Cinti, CR … - American Journal of …, 2007 - Am Physiological Soc We quantified uncoupling proteins (UCPs) in molar amounts and assessed proton conductance
in mitochondria isolated from interscapular brown adipose tissue (IBAT) and hindlimb muscle
[known from prior work to contain ectopic brown adipose tissue (BAT) interspersed ... Cited by 5 - Related articles - BL Direct - All 3 versions
S Boudina, H Bugger, S Sena, BT O'Neill, VG Zaha, O … - Circulation, 2009 - Am Heart Assoc Background—Diabetes-associated cardiac dysfunction is associated with mitochondrial dysfunction
and oxidative stress, which may contribute to left ventricular dysfunction. The contribution of altered
myocardial insulin action, independent of associated changes in systemic metabolism, is ... Cited by 6 - Related articles - All 4 versions
M Friederich, A Fasching, P Hansell, L Nordquist, F … - BBA-Bioenergetics, 2008 - Elsevier We have previously reported increased O 2 consumption unrelated to active transport by tubular
cells and up-regulated mitochondrial uncoupling protein (UCP)-2 expressions in diabetic
kidneys. It is presently unknown if the increased UCP-2 levels in the diabetic kidney ... Cited by 6 - Related articles - All 2 versions
X Li, JM May - Mitochondrion, 2002 - Elsevier Mitochondria generate potentially damaging amounts of superoxide and H 2 O 2 during oxidative
metabolism. Although many assays are available to measure mitochondrial H 2 O 2
generation, most detect H 2 O 2 that has escaped the organelle. To measure H 2 O 2 ... Cited by 6 - Related articles - All 3 versions
- ►diabetesjournals.org S Boudina, S Sena, H Theobald, X Sheng, JJ Wright, … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—db/db hearts exhibited reduced cardiac function and increased MVo 2 . Mitochondrial
reactive oxygen species (ROS) generation and lipid and protein peroxidation products were
increased. Mitochondrial proliferation was increased in db/db hearts, oxidative ... Cited by 42 - Related articles - BL Direct - All 4 versions
H Bugger, ED Abel, M Alterations - phjournal.org The metabolic syndrome includes obesity, insulin resistance, dys- lipidemia, and type 2 diabetes
mellitus. It increases the risk of de- veloping cardiovascular diseases, including heart failure.
Evidence is emerging that changes in energy metabolism might contribute to the ... Related articles - View as HTML - All 5 versions
WI Sivitz, MA Yorek - Antioxidants & Redox Signaling - liebertonline.com Page 1. 1 COMPREHENSIVE INVITED REVIEW MITOCHONDRIAL DYSFUNCTION IN
DIABETES: FROM MOLECULAR MECHANISMS TO FUNCTIONAL SIGNIFICANCE AND
THERAPEUTIC OPPORTUNITIES William I. Sivitz and Mark A. Yorek ... Related articles - All 3 versions
H Bugger, M Schwarzer, D Chen, A … - Cardiovascular …, 2009 - cardiovascres.oxfordjournals.org Page 1. Accepted Manuscript Proteomic Remodeling of Mitochondrial Oxidative
Pathways in Pressure Overload-induced Heart Failure Heiko Bugger2, §, Michael
Schwarzer1, Dong Chen4, Andrea Schrepper1, Paulo A. Amorim1, ... Related articles - All 3 versions
