- ►diabetesjournals.org MC Akerfeldt, J Howes, JY Chan, VA Stevens, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Cytokines and palmitate triggered ER stress in β-cells as evidenced
by increased phosphorylation of PKR-like ER kinase (PERK), eukaryotic initiation
factor (EIF)2α, and Jun NH 2 -terminal kinase (JNK) and increased ... Cited by 9 - Related articles - All 3 versions
- ►biologists.org DA Cunha, P Hekerman, L Ladriere, A Bazarra- … - Journal of cell science, 2008 - jcs.biologists.org Free fatty acids (FFA) cause apoptosis of pancreatic β-cells and might
contribute to β-cell loss in type 2 diabetes via the induction of endoplasmic
reticulum (ER) stress. We studied here the molecular mechanisms implicated ... Cited by 23 - Related articles - All 5 versions
Y Ariyama, Y Tanaka, H Shimizu, K Shimomura … - Metabolism, 2008 - Elsevier Low expression of antioxidant enzymes makes pancreatic β-cells susceptible to
cell damage by oxidative stress. Pancreatic β-cell loss caused by endoplasmic
reticulum stress is associated with the onset of diabetes mellitus. The ... Cited by 2 - Related articles - All 10 versions
D Eizirik, F Moore, D Flamez, F Ortis - Biochemical Society Transactions, 2008 - biochemsoctrans.org Accumulating evidence indicates that β-cells die by apoptosis in T1DM (Type 1
diabetes mellitus). Apoptosis is an active gene-directed process, and recent
observations suggest that β-cell apoptosis depends on the parallel and/or ... Cited by 9 - Related articles - Cached - BL Direct - All 6 versions
KT Chambers, JA Unverferth, SM Weber, RC … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—UPR activation correlates with β-cell death in interleukin
(IL)-1–treated rat islets. NO mediates both cytokine-induced UPR activation
and β-cell death as NO synthase inhibitors attenuate each of these IL-1– ... Cited by 10 - Related articles - BL Direct - All 7 versions
- ►endojournals.org D Mokhtari, JW Myers, N Welsh - Endocrinology, 2008 - Endocrine Soc The aim of the present investigation was to characterize the role of the MAPK
kinase kinase-1 (MEKK-1) in stress-induced cell death of insulin producing
cells. We observed that transient overexpression of the wild type MEKK-1 ... Cited by 4 - Related articles - BL Direct - All 3 versions
- ►endojournals.org M Boni-Schnetzler, J Thorne, G Parnaud, L … - Journal of Clinical Endocrinology & Metabolism, 2008 - Endocrine Soc Results: Gene array analysis of RNA from β-cells of individuals with T2DM
revealed increased expression of IL-1β mRNA. Real-time PCR confirmed increased
IL-1β expression in six of 10 T2DM samples, with minimal or no expression ... Cited by 6 - Related articles - All 4 versions
B Song, D Scheuner, D Ron, S Pennathur, … - The Journal of Clinical Investigation, 2008 - pubmedcentral.nih.gov The progression from insulin resistance to type 2 diabetes is caused by the
failure of pancreatic β cells to produce sufficient levels of insulin to meet
the metabolic demand. Recent studies indicate that nutrient fluctuations ... Cited by 22 - Related articles - All 7 versions
- ►diabetesjournals.org P Pirot, F Ortis, M Cnop, Y Ma, LM Hendershot … - Diabetes, 2007 - Am Diabetes Assoc Endoplasmic reticulum stress–mediated apoptosis may play an important role in
the destruction of pancreatic β-cells, thus contributing to the development of
type 1 and type 2 diabetes. One of the regulators of endoplasmic reticulum ... Cited by 23 - Related articles - BL Direct - All 8 versions
EN Gurzov, F Ortis, L Bakiri, EF Wagner, DL … - PLoS One, 2008 - pubmedcentral.nih.gov Cytokines contribute to pancreatic β-cell apoptosis in type 1 diabetes (T1D) by
modulation of β-cell gene expression networks. The transcription factor
Activator Protein-1 (AP-1) is a key regulator of inflammation and ... Cited by 7 - Related articles - All 7 versions
