- ►diabetesjournals.org L Marzban, A Tomas, TC Becker, L Rosenberg, J … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Thioflavine S–positive amyloid deposits were clearly present after 10 days of
culture. Transduction with Ad-hProIAPP-siRNA reduced proIAPP expression by 75% compared
with nontransduced islets as assessed by Western blot analysis of islet lysates 4 days ... Cited by 5 - Related articles - All 3 versions
- ►physiology.org RL Hull, S Zraika, J Udayasankar, R … - American Journal of …, 2007 - Am Physiological Soc Deposition of islet amyloid polypeptide (IAPP) as amyloid in the pancreatic islet occurs in 90%
of individuals with Type 2 diabetes and is associated with decreased islet β-cell mass and
function. Human IAPP (hIAPP), but not rodent IAPP, is amyloidogenic and toxic to islet β- ... Cited by 6 - Related articles - BL Direct - All 4 versions
E Karlsson, S Sandler - Diabetologia, 2001 - Springer Aims/hypothesis. We aimed to clarify the role of islet amyloid polypeptide, which is expressed
at early em- bryonic onset, in the proliferation and cell death of neonatal islet cells. Methods.
Fetal islets were prepared from pregnant rats on gestational day 21. Islets were cultured ... Cited by 5 - Related articles - BL Direct - All 4 versions
J Olerud, A Johansson, PO Carlsson - Expert Review of …, 2009 - ingentaconnect.com Since the different endocrine cell types have dis- tinct locations in the rodent pancreas, with
b-cells mainly located in the core region, the direction of intra-islet blood perfusion has been
proposed to have significant impact on cell intercommu- nication within the islet. ... Related articles - All 3 versions
J Xu, YS Long, D Gozal, PN Epstein - Free Radical Biology and Medicine, 2009 - Elsevier Intermittent hypoxia (IH), such as occurs in sleep apnea, induces increased oxidative stress and
is associated with altered glucose homeostasis. Because pancreatic β cells are very sensitive
to oxidative stress we tested whether they could be affected by IH. The effects of IH ... Cited by 1 - Related articles - All 2 versions
KJ Potter, LA Scrocchi, GL Warnock, Z Ao, MA Younker, … - BBA-General Subjects, 2009 - Elsevier Amyloid fibrils created by misfolding and aggregation of proteins are a major pathological feature
in a variety of degenerative diseases. Therapeutic approaches including amyloid vaccines and
anti-aggregation compounds in models of amyloidosis point to an important role for ... Related articles - All 2 versions
Y Zhang, F Ranta, C Tang, E Shumilina, H Mahmud, M … - Apoptosis, 2009 - Springer Abstract Amyloid peptides interfere with survival of pancreatic beta-cells. In some cells apoptosis
is paralleled by ceramide-dependent alterations of ion channel activity. The purpose of the present
study was to elucidate the dependence of amyloid peptides Aß 1-42 and islet amyloid ... Related articles - All 2 versions
- ►amjpathol.org E Favaro, I Miceli, B Bussolati, M Schimitt-Ney, P … - American Journal of …, 2008 - ASIP Pancreatic islet microendothelium and β cells exhibit an interdependent physical and functional
relationship. In this study, we analyzed the effect of chronic hyperglycemia on human pancreatic
islet microendothelial cells as well as the involvement of the phosphatidylinositol 3-kinase/ ... Cited by 1 - Related articles - All 4 versions
HL Zhao, Y Sui, J Guan, L He, XM Gu, HK Wong, L … - Translational Research, 2009 - Elsevier The amyloid hypothesis of type 2 diabetes mellitus postulates that elevated levels of normally
expressed monomeric proteins of human islet amyloid polypeptide (hIAPP) trigger oligomerization
that independently causes fibril formation and disease progression. The aim of this study ... Cited by 1 - Related articles - All 12 versions
