H Lango, CNA Palmer, AD Morris, E Zeggini, AT … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVES—Genome-wide association studies have dramatically increased the number of
common genetic variants that are robustly associated with type 2 diabetes. A possible clinical
use of this information is to identify individuals at high risk of developing the disease, so ... Cited by 28 - Related articles - All 5 versions
- ►diabetesjournals.org M van Hoek, A Dehghan, J Witteman, CM van Duijn, … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—We investigated 18 polymorphisms from recent GWA
studies on type 2 diabetes in the Rotterdam Study, a prospective, population-based study among
homogeneous Caucasian individuals of 55 years and older (genotyped subjects, n = ... Cited by 33 - Related articles - All 4 versions
N Grarup, G Andersen, NT Krarup, A Albrechtsen, O … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— Homozygous carriers of the minor diabetes risk G-allele of the CDC123/CAMK1D
rs12779790 showed an 18% decrease in insulinogenic index (95% CI 10–27%; P = 4 × 10
−5 ), an 18% decrease in corrected insulin response (CIR) (8.1–29%; P = 4 × 10 −4 ), and ... Cited by 16 - Related articles - All 6 versions
UK Oxford, M Weedon - pbrc.edu 1. Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical
School, Magdalen Road, Exeter, UK 2. Diabetes Genetics, Institute of Biomedical and Clinical
Science, Peninsula Medical School, Barrack Road, Exeter, UK 3. Population ... Related articles - View as HTML - All 2 versions
- ►diabetesjournals.org M Vaxillaire, J Veslot, C Dina, C Proença, S Cauchi, G … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— The GCK (Glucokinase) −30A allele was associated with increased type 2 diabetes
risk at the end of the follow-up study (adjusted OR 1.34 [95% CI 1.07–1.69]) under an additive
model, as supported in independent French diabetic case subjects (OR 1.22, P = 0.007), ... Cited by 34 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] N Grarup, CS Rose, EA Andersson, G Andersen, AL … - Diabetes, 2007 - Am Diabetes Assoc Page 1. Studies of Association of Variants Near the HHEX, CDKN2A/B, and IGF2BP2
Genes With Type 2 Diabetes and Impaired Insulin Release in 10,705 Danish Subjects
Validation and Extension of Genome-Wide Association Studies ... Cited by 60 - Related articles - BL Direct - All 3 versions
- ►prsjournal.net ACJW Janssens, R Moonesinghe, Q Yang, EW … - Genetics in …, 2007 - journals.lww.com Purpose: Single genetic variants in multifactorial disorders typically have small effects, so major
increases in disease risk are expected only from the simultaneous exposure to multiple risk
genotypes. We investigated the impact of genotype frequencies on the clinical ... Cited by 21 - Related articles - BL Direct - All 7 versions
T Sparsø, G Andersen, A Albrechtsen, T Jørgensen, K … - Diabetologia, 2008 - Springer Abstract Aim/hypothesis Recently, variants in WFS1 have been shown to be associated with
type 2 diabetes. We aimed to examine metabolic risk phenotypes of WFS1 variants in
glucose- tolerant people and in individuals with abnormal glucose regulation. Methods ... Cited by 7 - Related articles - All 3 versions
- ►diabetesjournals.org W Winckler, MN Weedon, RR Graham, SA McCarroll, S … - Diabetes, 2007 - Am Diabetes Assoc An important question in human genetics is the extent to which genes causing monogenic forms
of disease harbor common variants that may contribute to the more typical form of that
disease. We aimed to comprehensively evaluate the extent to which common variation in ... Cited by 56 - Related articles - BL Direct - All 5 versions
S Cauchi, D Meyre, E Durand, C Proença, M Marre, S … - PloS one, 2008 - pubmedcentral.nih.gov In the same French population analyzed in our previous GWA study (3,295 T2D and 3,595
NGT), strong associations with T2D were found for CDKAL1 (OR rs7756992 =
1.30[1.19–1.42], P = 2.3×10 −9 ), CDKN2A/2B (OR rs10811661 = 0.74[0.66–0.82], P = ... Cited by 21 - Related articles - All 7 versions
