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Scholar Results 1 - 10 of about 101 related to Proulx: Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin.... (0.18 sec) 

Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin …

- diabetesjournals.org
K Proulx, D Cota, SC Woods, RJ Seeley - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—Evidence links the hypothalamic fatty acid synthase (FAS) pathway to
the regulation of food intake and body weight. This includes pharmacological
inhibitors that potently reduce feeding and body weight. The mammalian ...
Cited by 3 - Related articles - All 3 versions

Brain lipogenesis and regulation of energy metabolism


M López, A Vidal-Puig - Current Opinion in Clinical Nutrition & Metabolic Care, 2008 - journals.lww.com
Recent findings: The 'classical' hypothalamic neuropeptide view of feeding
regulation has been extensively reviewed and revised during the past few years.
Accumulating evidence indicates that the modulation of lipogenesis de novo ...
Cited by 4 - Related articles - All 2 versions

Critical role for hypothalamic mTOR activity in energy balance

- cell.com
H Mori, K Inoki, H Münzberg, D Opland, M … - Cell Metabolism, 2009 - Elsevier
The mammalian target of rapamycin (mTOR) promotes anabolic cellular processes in
response to growth factors and metabolic cues. The TSC1 and TSC2 tumor
suppressors are major upstream inhibitory regulators of mTOR signaling. ...
Cited by 4 - Related articles - All 4 versions

The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet- …

- cjb.net
D Cota, EK Matter, SC Woods, RJ Seeley - Journal of Neuroscience, 2008 - neuro.cjb.net
The mammalian target of rapamycin (mTOR) kinase is a key regulator of several
cellular functions, including cell growth and differentiation. Because
hypothalamic mTOR complex 1 (mTORC1) signaling has been implicated as a ...
Cited by 10 - Related articles - All 6 versions

The role of transcriptional regulators in central control of appetite and body weight


R Coppari, G Ramadori, JK Elmquist - Nature Clinical Practice Endocrinology & Metabolism, 2009 - nature.com
Roberto Coppari received a Ph.D. in Neuroscience in 2002. Dr Coppari spent five
years (2000–2005) in the laboratory directed by Dr. Bradford Lowell at Harvard
Medical School. During that time, Dr Coppari's interests on understanding ...
Cited by 2 - Related articles - All 3 versions

Impaired central insulin response in aged Wistar rats: Role of adiposity

- endojournals.org
M Garcia-San Frutos, T Fernandez-Agullo, AJ … - Endocrinology, 2007 - Endocrine Soc
Insulin, like leptin, is considered as a lipostatic signal acting at a central
level. Aging and age-associated adiposity have been related to the development
of leptin resistance in Wistar rats. In the present article, hypothalamic ...
Cited by 2 - Related articles - All 3 versions

Tuberous sclerosis complex activity is required to control neuronal stress responses in …

- jneurosci.org
A Di Nardo, I Kramvis, N Cho, A Sadowski, L … - Journal of Neuroscience, 2009 - Soc Neuroscience
Tuberous sclerosis complex (TSC) is a neurogenetic disorder caused by
loss-of-function mutations in either the TSC1 or TSC2 genes and frequently
results in prominent CNS manifestations, including epilepsy, mental ...
Cited by 3 - Related articles - All 3 versions

Characteristics and mechanisms of hypothalamic neuronal fatty acid sensing


C Le Foll, BG Irani, C Magnan, AA Dunn- … - … Journal of Physiology- Regulatory, Integrative and …, 2009 - Am Physiological Soc
We assessed the mechanisms by which specialized hypothalamic ventromedial
nucleus (VMN) neurons utilize both glucose and long-chain fatty acids as
signaling molecules to alter their activity as a potential means of ...
Cited by 3 - Related articles - All 3 versions

Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via AMP- …

- endojournals.org [PDF] 
H Shimizu, H Arima, M Watanabe, M Goto, R … - Endocrinology, 2008 - Endocrine Soc
Page 1. 1 Title Page Glucocorticoids Increase Neuropeptide Y and
Agouti-Related Peptide Gene Expression via AMP-Activated Protein ...
Cited by 3 - Related articles

NF-κB activated by ER calcium release inhibits Aβ-mediated expression of CHOP protein: …


J Schapansky, K Olson, R Van Der Ploeg, G … - Experimental Neurology, 2007 - Elsevier
Mutations in presenilin which result in early-onset Alzheimer disease (AD) cause
both increased calcium release from intracellular stores, primarily endoplasmic
reticulum (ER), and changes in NF-κB activation. Some studies have also ...
Cited by 3 - Related articles - All 2 versions


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