- ►diabetesjournals.org YG Chen, F Scheuplein, MA Osborne, SW … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Although the H2 g7 major histocompatibility complex (MHC) provides
the primary pathogenic component, the development of T-cell–mediated
autoimmune type 1 diabetes in NOD mice also requires contributions from ... Related articles - All 3 versions
- ►jimmunol.org PA Silveira, HD Chapman, J Stolp, E Johnson … - The Journal of Immunology, 2006 - Am Assoc Immnol Autoreactive T cells clearly mediate the pancreatic β cell destruction causing
type 1 diabetes (T1D). However, studies in NOD mice indicate that B cells also
contribute to pathogenesis because their ablation by introduction of an ... Cited by 7 - Related articles - BL Direct - All 4 versions
PC Reifsnyder, R Li, PA Silveira, G Churchill, … - Genes and Immunity, 2005 - nature.com While sharing the H2 g7 MHC and many other important Type I diabetes
susceptibility (Idd) genes with NOD mice, the NOR strain remains disease free
due to resistance alleles within the 12% portion of their genome that is of ... Cited by 10 - Related articles - BL Direct - All 3 versions
HZ Mao, ET Roussos, M Péterfy - BBA-Molecular Basis of Disease, 2006 - Elsevier The C57BLKS/J (BKS) inbred mouse strain is a widely used animal model of type 2
diabetes. In the presence of the diabetes (db) mutation, obese BKS-db mice
develop severe diabetes. Genetic studies of diabetes-susceptibility in this ... Cited by 4 - Related articles - All 4 versions
- ►jimmunol.org W Yang, S Hussain, QS Mi, P Santamaria, TL … - The Journal of Immunology, 2004 - Am Assoc Immnol Activation-induced cell death (AICD) plays a key role in the homeostasis of the
immune system. Autoreactive T cells are eliminated through AICD both from the
thymus and periphery. In this study, we show that NOD peripheral T cells, ... Cited by 4 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org T Takaki, SM Lieberman, TM Holl, B Han, P … - The Journal of Immunology, 2004 - Am Assoc Immnol The NOD mouse is a model for autoimmune type 1 diabetes in humans. CD8 + T cells
are essential for the destruction of the insulin-producing pancreatic cells
characterizing this disease. AI4 is a pathogenic CD8 + T cell clone, ... Cited by 11 - Related articles - BL Direct - All 4 versions
- ►oxfordjournals.org M O'Keeffe, TC Brodnicki, B Fancke, D … - International immunology, 2005 - Jpn Soc Immunol A dendritic cell (DC) imbalance with a marked deficiency in CD4 – 8 + DC
occurs in non-obese diabetic (NOD) mice, a model of human autoimmune diabetes
mellitus. Using a NOD congenic mouse strain, we find that this CD4 – 8 + ... Cited by 12 - Related articles - All 5 versions
- ►diabetesjournals.org YG Chen, PA Silveira, MA Osborne, HD … - Diabetes, 2007 - Am Diabetes Assoc The H2 g7 (K d , A g7 , E null , and D b ) major histocompatibility complex
(MHC) is the primary genetic contributor to type 1 diabetes in NOD mice. NOD
stocks congenically expressing other MHC haplotypes such as H2 nb1 (K b , A ... Cited by 2 - Related articles - BL Direct - All 5 versions
JL Cannons, G Chamberlain, J Howson, LJ … - Journal of Autoimmunity, 2005 - Elsevier Idd9.3, a locus that determines susceptibility to the autoimmune disease type 1
diabetes (T1D) in the nonobese diabetic (NOD) mouse, has been mapped to the
distal region of chromosome 4. In the current report we reduce the size of ... Cited by 19 - Related articles - All 3 versions
- ►jimmunol.org CM Choisy-Rossi, TM Holl, MA Pierce, HD … - The Journal of Immunology, 2004 - Am Assoc Immnol For unknown reasons, the common MHC class I variants encoded by the H2 g7
haplotype (K d , D b ) aberrantly elicit autoreactive CD8 T cell responses
essential to type 1 diabetes development when expressed in NOD mice, but ... Cited by 27 - Related articles - BL Direct - All 4 versions
