VP Singh, B Le, R Khode, KM Baker, R Kumar - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Many of the effects of angiotensin (Ang) II are mediated through
specific plasma membrane receptors. However, Ang II also elicits biological
effects from the interior of the cell (intracrine), some of which are not ... Cited by 9 - Related articles - All 3 versions
- ►physiology.org VP Singh, KM Baker, R Kumar - American Journal of Physiology- Heart and Circulatory …, 2008 - Am Physiological Soc The occurrence of a functional intracellular renin-angiotensin system (RAS) has
emerged as a new paradigm. Recently, we and others demonstrated intracellular
synthesis of ANG II in cardiac myocytes and vascular smooth muscle cells ... Cited by 9 - Related articles - BL Direct - All 3 versions
- ►problemsinanes.com R Kumar, VP Singh, KM Baker - Current Opinion in Nephrology and Hypertension, 2008 - journals.lww.com Purpose of review: The renin-angiotensin system, traditionally viewed as a
circulatory system, has significantly expanded in the last two decades to
include independently regulated local systems in several tissues, newly ... Cited by 17 - Related articles - BL Direct - All 12 versions
R Singh, DJ Leehey - Biochemical and Biophysical Research …, 2007 - Elsevier This study investigates whether angiotensin converting enzyme (ACE) inhibitors
can block high glucose-induced increase of angiotensin II (Ang II) levels in
cultured rat mesangial cells. Incubation of cells with high glucose for 5 ... Cited by 10 - Related articles - All 6 versions
J Peters - Journal of Molecular Medicine, 2008 - Springer Abstract Renin is commonly known as a secretory glycoprotein, which is
expressed, stored, and secreted in a regulated manner by the kidney. The rat
kidney exclusively expresses secretory renin. In this organ, renin ... Cited by 5 - Related articles - BL Direct - All 3 versions
R Re - American Journal of Physiology- Heart and Circulatory …, 2008 - Am Physiological Soc IT IS AXIOMATIC THAT PEPTIDE hormones bind to cognate receptors on target cells,
with the resultant generation of intracellular second messengers. Not as well
known is the fact that a large and growing body of evidence indicates that ... Cited by 11 - Related articles - BL Direct - All 5 versions
- ►physiology.org KM Baker, R Kumar - American Journal of Physiology- Cell Physiology, 2006 - Am Physiological Soc We recently reported intracrine effects of angiotensin II (ANG II) on cardiac
myocyte growth and hypertrophy that were not inhibited by the ANG II type 1
receptor (AT 1 ) antagonist, losartan. To further determine the role of AT ... Cited by 22 - Related articles - BL Direct - All 3 versions
- ►cell.com R Kumar, VP Singh, KM Baker - Trends in Endocrinology & Metabolism, 2007 - Elsevier More than a century after its discovery, the physiological implications of the
renin–angiotensin system (RAS) continue to expand, with the identification of
new components, functions and subsystems. These advancements have led to ... Cited by 16 - Related articles - All 5 versions
Y Hong, J Dingemanse, DE Mager, 2008 - nature.com A semimechanistic pharmacokinetic/pharmacodynamic (PK/PD) model was developed to
evaluate the effects of aliskiren on the renin–angiotensin system (RAS) in
humans. Mean data were extracted from a three-way crossover, ... Cited by 8 - Related articles - All 5 versions
M Krop, IM Garrelds, RJA de Bruin, JMG van … - Hypertension, 2008 - Am Heart Assoc The vascular effects of aliskiren last longer than expected based on its half
life, and this renin inhibitor has been reported to cause a greater renin rise
than other renin-angiotensin system blockers. To investigate whether ... Cited by 9 - Related articles - All 6 versions
