- ►diabetesjournals.org E Mariño, M Batten, J Groom, S Walters, D Liuwantara, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—We demonstrate that splenic MZB numbers in female NOD mice undergo a
marked, approximately threefold expansion between ∼12 and 16 weeks of age, coincident with
the onset of frank diabetes. Functionally, NOD MZBs are hyperresponsive to toll-like ... Cited by 8 - Related articles - BL Direct - All 3 versions
G Zekavat, SY Rostami, A Badkerhanian, RF … - The Journal of …, 2008 - Am Assoc Immnol B lymphocytes are required for the pathogenesis of autoimmune diabetes in NOD mice. Previous
studies established that a lymphopenic transitional (TR) B cell compartment reduces the competitive
constraint on the entry of newly emerging TR B cells into the splenic follicle (FO), thereby ... Cited by 6 - Related articles - All 4 versions
GM Brodie, M Wallberg, P Santamaria, FS Wong, EA … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—RIP-TNFα-NOD mice were crossed to B-cell–deficient
NOD mice, and diabetes development was monitored. We used in vitro antigen presentation
assays and in vivo administration of bromodeoxyuridine coupled to flow cytometry assays ... Cited by 12 - Related articles - BL Direct - All 3 versions
- ►jimmunol.org PA Silveira, HD Chapman, J Stolp, E … - The Journal of …, 2006 - Am Assoc Immnol Autoreactive T cells clearly mediate the pancreatic β cell destruction causing type 1 diabetes
(T1D). However, studies in NOD mice indicate that B cells also contribute to pathogenesis because
their ablation by introduction of an Igµ null mutation elicits T1D resistance. T1D ... Cited by 7 - Related articles - BL Direct - All 4 versions
FD Dufour, AG Baxter, PA Silveira - Journal of Immunotoxicology, 2008 - informahealthcare.com Type 1 diabetes is one of the most prevalent autoimmune conditions that develops during childhood
and has an increasing incidence worldwide. The disease results from the destruction of pancreatic
β cells mediated by autoreactive T-lymphocytes. In order to develop preventive therapies, ... Cited by 2 - Related articles - All 7 versions
- ►lambris.net [PDF] H Noorchashm, DJ Moore, YK Lieu, N Noorchashm, A … - Cellular Immunology, 1999 - Elsevier B lymphocytes are required for diabetogenesis in nonobese diabetic (NOD) mice. The complement
component of the innate immune system regulates B cell activation and tolerance through complement
receptors CR1/CR2. Thus, it is important to assess the contribution of complement ... Cited by 24 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org J Rolf, V Motta, N Duarte, M Lundholm, E … - The Journal of …, 2005 - Am Assoc Immnol The NOD mouse is an important experimental model for human type 1 diabetes. T cells are central
to NOD pathogenesis, and their function in the autoimmune process of diabetes has been well
studied. In contrast, although recognized as important players in disease induction, the ... Cited by 20 - Related articles - All 5 versions
- ►jimmunol.org WJ Quinn III, N Noorchashm, JE Crowley, AJ … - The Journal of …, 2006 - Am Assoc Immnol Developing B cells undergo selection at multiple checkpoints to eliminate autoreactive
clones. We analyzed B cell kinetics in the NOD mouse to establish whether these checkpoints
are intact. Our results show that although bone marrow production is normal in NOD mice, ... Cited by 10 - Related articles - BL Direct - All 6 versions
PA Silveira, ST Grey - Trends in Endocrinology & Metabolism, 2006 - Elsevier It has long been established that type 1 diabetes (T1D) is a T cell-mediated autoimmune
disease, with CD4 + and CD8 + T cells being largely responsible for the destruction of β cells
within the pancreatic islets of Langerhans. Although autoantibodies specific for islet cell ... Cited by 24 - Related articles - All 6 versions
L Yu, GS Eisenbarth - Immunology of type 1 diabetes, 2004 - books.google.com CHAPTER 10 Humoral Autoimmunity Liping Yu and George S. Eisenbarth A litde more than
a decade ago, screening for autoantibodies associated with Type 1A (immune mediated) diabetes
was limired ro measuring cytoplasmic islet cell autoantibodies (ICAs) and insulin ... Cited by 11 - Related articles - All 3 versions
