- ►diabetesjournals.org DK Hagman, MG Latour, SK Chakrabarti, G Fontes, J … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Prolonged exposure of isolated islets of Langerhans to elevated levels of fatty
acids, in the presence of high glucose, impairs insulin gene expression via a transcriptional mechanism
involving nuclear exclusion of pancreas-duodenum homeobox-1 (Pdx-1) and loss of ... Cited by 5 - Related articles - BL Direct - All 4 versions
V Plaisance, V Perret, D Favre, A Abderrahmani, JY … - Molecular and Cellular …, 2009 - Elsevier Fatty acids can favour the development of Type 2 diabetes by reducing insulin secretion and
inducing apoptosis of pancreatic β-cells. Here, we show that sustained exposure of the β-cell
line MIN6 or of isolated pancreatic islets to the most abundant circulating fatty acid ... Cited by 2 - Related articles - All 2 versions
- ►umin.ac.jp [PDF] M Ishikawa, Y Iwasaki, S Yatoh, T Kato, S … - The Journal of Lipid …, 2008 - ASBMB To determine the role of cholesterol synthesis in pancreatic β-cells, a transgenic model of in vivo
activation of sterol-regulatory element binding protein 2 (SREBP-2) specifically in β-cells
(TgRIP-SREBP-2) was developed and analyzed. Expression of nuclear human SREBP-2 ... Cited by 2 - Related articles - All 7 versions
K Fujimoto, KS Polonsky - Diabetes, Obesity and Metabolism, 2009 - interscience.wiley.com A progressive reduction in β-cell mass occurs in the evolution of diabetes. Thus understanding
the mechanisms responsible for this reduction in β-cell mass is important for understanding the
pathogenesis of diabetes and in developing novel approaches to prevention and ... Related articles - All 3 versions
G Fontés, M Semache, DK Hagman, C Tremblay, R … - Diabetes, 2009 - biochem.utah.edu Involvement of Per-Arnt-Sim Kinase and ... Inhibition of Insulin Gene Expression in Pancreatic
ß-Cells ... Ghislaine Fontés,1,2 Meriem Semache,1 Derek K. Hagman,1,2 Caroline
Tremblay,1 Ramila Shah,3 Christopher J. Rhodes,3 Jared Rutter,4 and Vincent Poitout1,2 Related articles - View as HTML - All 4 versions
WF Graier, R Malli, GM Kostner - Trends in Endocrinology & Metabolism, 2009 - Elsevier Lipotoxicity occurs as a consequence of chronic exposure of non-adipose tissue and cells to
elevated concentrations of fatty acids, triglycerides and/or cholesterol. The contribution of mitochondria
to lipotoxic cell dysfunction, damage and death is associated with elevated production of ... Cited by 1 - Related articles - All 3 versions
J Cantley, JG Burchfield, GL Pearson, C Schmitz- … - Diabetes, 2009 - Am Diabetes Assoc Results: The enhanced GSIS could not be explained by increased expression of another PKC
isoform or by alterations in glucose stimulated Ca 2+ influx. Instead an up-regulation of the amplifying
pathways of GSIS in lipid-cultured PKCεKO β-cells was revealed under conditions in ... Cited by 2 - Related articles - All 3 versions
G Fontés, M Semache, DK Hagman, C Tremblay, R … - Diabetes, 2009 - ncbi.nlm.nih.gov Objective: Prolonged exposure of pancreatic beta cells to simultaneously elevated levels of fatty
acids and glucose (glucolipotoxicity) impairs insulin gene transcription. However, the intracellular
signalling pathways mediating these effects are mostly unknown. This study was aimed to ... Cited by 1 - Related articles - All 3 versions
- ►nih.gov C Evans-Molina, RD Robbins, T Kono, SA … - Molecular and Cellular …, 2009 - Am Soc Microbiol The nuclear receptor peroxisome proliferator-activated receptor (PPAR- ) is an important target
in diabetes therapy, but its direct role, if any, in the restoration of islet function has remained
controversial. To identify potential molecular mechanisms of PPAR- in the islet, we treated ... Cited by 2 - Related articles - All 4 versions
K Fujimoto, PT Hanson, H Tran, EL Ford, Z Han, JD … - Journal of Biological …, 2009 - ASBMB There are three types of cell death; apoptosis, necrosis, and autophagy. The possibility that activation
of the macroautophagy (autophagy) pathway may increase beta cell death is addressed in this
study. Increased autophagy was present in pancreatic islets from Pdx1 +/− mice with ... Cited by 1 - Related articles - All 3 versions
