- ►diabetesjournals.org RJ McCrimmon, M Shaw, X Fan, H Cheng, Y Ding, MC … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—Using gene silencing technology to selectively downregulate
AMPK in the VMH, a key hypothalamic glucose-sensing region, we demonstrate a key role for
AMPK in the detection of hypoglycemia. In vivo hyperinsulinemic-hypoglycemic (50 mg dl ... Cited by 12 - Related articles - BL Direct - All 3 versions
[CITATION] de BP, Luiten PG, van Willigen JD. Ascending projections from the solitary tract …
- ►nih.gov J Chen, KA Scott, Z Zhao, TH Moran, S Bi - Neuroscience, 2008 - Elsevier Within the dorsomedial hypothalamus (DMH), cholecystokinin (CCK) has been proposed to modulate
neuropeptide Y (NPY) signaling to affect food intake. However, the neural circuitry underlying
the actions of this CCK-NPY signaling system in the controls of food intake has yet to be ... Cited by 7 - Related articles - All 4 versions
- ►imperial.ac.uk [PDF] NM Martin, KL Smith, SR Bloom, CJ Small - Peptides, 2006 - Elsevier Recent studies of transgenic mice and humans have provided compelling evidence for the importance
of the hypothalamic melanocortin system in the regulation of energy balance. Energy homeostasis
is a balance between food intake (energy input) and energy expenditure. The ... Cited by 16 - Related articles - All 12 versions
JE Wikberg, F Mutulis - Nature Reviews Drug Discovery, 2008 - farmbio.uu.se The melanocortins are a family of peptides that are derived from a common precursor
protein, pro-opiomelanocortin (POMC). POMC is expressed in neurons of the central and peripheral
nervous system, and in the pituitary. Its proteolytic cleavage results in α-, β- and γ- ... Cited by 14 - Related articles - View as HTML - BL Direct - All 4 versions
YB Shrestha, K Wickwire, SQ Giraudo - Neuroreport, 2004 - journals.lww.com Ghrelin is a 28 amino-acid peptide that has been shown to induce positive energy balance when
administered both peripherally and centrally. This effect appears to occur by increasing food
intake and by reducing fat utilization. Ghrelin injected into the PVN increases food intake ... Cited by 14 - Related articles - BL Direct - All 3 versions
[CITATION] Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond …
- ►diabetesjournals.org O Chan, H Cheng, R Herzog, D Czyzyk, W Zhu, A … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Quantitative RT-PCR and immunoblots in recurrently hypoglycemic animals revealed
that GAD 65 mRNA and protein were increased 33 and 580%, respectively. Basal VMH GABA
concentrations were more than threefold higher in recurrently hypoglycemic animals. ... Cited by 4 - Related articles - BL Direct - All 4 versions
- ►endojournals.org MM Kamiji, A Inui - Endocrine reviews, 2007 - Endocrine Soc Obesity is a serious public health problem throughout the world, affecting both developed societies
and developing countries. The central nervous system has developed a meticulously interconnected
circuitry in order to keep us fed and in an adequate nutritional state. One of these ... Cited by 18 - Related articles - BL Direct - All 3 versions
PD Mountjoy, SJ Bailey, GA Rutter - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Changes in the activity of glucose-excited and glucose-inhibited neurons
within the basomedial hypothalamus are key to the central regulation of satiety. However, the
molecular mechanisms through which these cells respond to extracellular stimuli remain ... Cited by 25 - Related articles - BL Direct - All 6 versions
