- ►diabetesjournals.org V Thallas-Bonke, SR Thorpe, MT Coughlan, K Fukami, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Apocynin attenuated diabetes-associated increases in albuminuria and
glomerulosclerosis. Circulating, renal cytosolic, and skin collagen–associated AGE levels in
diabetic rats were not reduced by apocynin. Diabetes-induced translocation of PKC, ... Cited by 27 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] V Thallas-Bonke, SR Thorpe, MT Coughlan, K Fukami, … - Diabetes, 2007 - Am Diabetes Assoc Page 1. Inhibition of NADPH oxidase prevents AGE mediated damage in diabetic
nephropathy through a protein kinase C-α dependent pathway. Vicki Thallas-Bonke
1 (BAppSci ) , Suzanne R Thorpe 2 (PhD), Melinda T. Coughlan 1 ... Cited by 6 - Related articles - All 2 versions
- ►asnjournals.org KR Tuttle, JB McGill, DJ Haney, TE Lin, PW … - Clinical Journal of the …, 2007 - Am Soc Nephrol Background: A pilot study showed that ruboxistaurin (RBX), a protein kinase C ß inhibitor, significantly
decreased albuminuria and stabilized kidney function over 1 yr in patients who had diabetic
nephropathy and persistent macroalbuminuria despite receiving the current standard of ... Cited by 15 - Related articles - BL Direct - All 3 versions
- ►physiology.org [PDF] XF Wei, QG Zhou, FF Hou, BY Liu, M … - American Journal of …, 2008 - Am Physiological Soc Page 1. 1 1 Advanced oxidation protein products induce mesangial cells perturbation
through PKC-dependent activation of NADPH oxidase Xiao Fan Wei*2, Qiu Gen
Zhou*2, Fan Fan Hou*1, Bei Yi Liu†, Min Liang* Southern ... Cited by 6 - Related articles - All 3 versions
- ►endojournals.org XY Shi, FF Hou, HX Niu, GB Wang, D Xie, ZJ Guo, ZM … - Endocrinology, 2008 - Endocrine Soc The involvement of inflammatory processes has been recognized in development and/or progression
of diabetic nephropathy. However, the mechanisms involved in the pathogenesis of renal inflammation
have not been completely understood. In this study, we tested the hypothesis that ... Cited by 17 - Related articles - BL Direct - All 3 versions
Y Ohshiro, RC Ma, Y Yasuda, J Hiraoka-Yamamoto, … - Diabetes, 2006 - Am Diabetes Assoc Diabetes induces the activation of several protein kinase C (PKC) isoforms in the renal
glomeruli. We used PKC-β −/− mice to examine the action of PKC-β isoforms in diabetes-induced
oxidative stress and renal injury at 8 and 24 weeks of disease. Diabetes increased PKC ... Cited by 38 - Related articles - BL Direct - All 6 versions
H Noh, GL King - Kidney International, 2007 - nature.com Diabetic nephropathy is the leading cause of end-stage renal disease worldwide and an independent
risk factor for all-cause and cardiovascular mortalities in diabetic patients. New insights into the
molecular mechanisms that underlie the development and progression of microvascular ... Cited by 11 - Related articles - BL Direct - All 2 versions
A Ustundag, A Tugrul, S Ustundag, N Sut, B … - Renal …, 2008 - informahealthcare.com Increasing evidence suggests that circulating aldosterone per se contributes directly to renal
and cardiovascular diseases. We sought to evaluate the effects of a three-month treatment with
25 mg spironolactone, an aldosterone receptor antagonist, on nephron function in 20 type ... Cited by 2 - Related articles - All 5 versions
GL Bakris - Clinical Journal of the American Society of Nephrology, 2007 - Am Soc Nephrol Kinases transfer the terminal, "high energy" phosphate group of ATP to a site on a target
protein, thereby activating the protein, which may be an enzyme, cell membrane receptor, or
ion transport channel. The protein kinase C (PKC) family is a group of such enzymes that ... Cited by 2 - Related articles - BL Direct - All 3 versions
S Tang, V Xiao, L Wei, CI Whiteside, LP … - Proteins: Structure, …, 2008 - interscience.wiley.com Protein kinase C (PKC) isozymes are an important class of enzymes in cell signaling and as
drug targets. They are involved in specific pathways and have selectivity towards certain
ligands, despite their high sequence similarities. Ruboxistaurin is a specific inhibitor of ... Cited by 2 - Related articles - BL Direct - All 2 versions
