- ►diabetesjournals.org L Shu, NS Sauter, FT Schulthess, AV Matveyenko, J … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—To investigate the effects of TCFL7L2 depletion, isolated
islets were exposed to TCF7L2 small interfering RNA (siRNA) versus scrambled siRNA, and
β-cell survival and function were examined. For TCF7L2 overexpression, islets were ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►nih.gov SA Schäfer, O Tschritter, F Machicao, C Thamer, N … - Diabetologia, 2007 - Springer Page 1. ARTICLE Impaired glucagon-like peptide-1-induced insulin secretion in carriers of
transcription factor 7-like 2 (TCF7L2) gene polymorphisms SA Schäfer & O. Tschritter & F.
Machicao & C. Thamer & N. Stefan & B. Gallwitz & JJ Holst & JM Dekker & ... Cited by 57 - Related articles - BL Direct - All 9 versions
- ►jbc.org Z Liu, JF Habener - Journal of Biological Chemistry, 2008 - ASBMB The insulinotropic hormone GLP-1 (glucagon-like peptide-1) is a new therapeutic agent that
preserves or restores pancreatic beta cell mass. We report that GLP-1 and its agonist,
exendin-4 (Exd4), induce Wnt signaling in pancreatic beta cells, both isolated islets, and ... Cited by 34 - Related articles - All 4 versions
- ►nih.gov V Lyssenko, L Groop - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig Genetic variants in the gene encoding for transcription factor-7–like 2 (TCF7L2) have been associated
with type 2 diabetes (T2D) and impaired β cell function, but the mechanisms have remained
unknown. We therefore studied prospectively the ability of common variants in TCF7L2 to ... Cited by 136 - Related articles - BL Direct - All 13 versions
- ►utah.edu [PDF] JC Florez - Current Opinion in Clinical Nutrition & Metabolic Care, 2007 - journals.lww.com Purpose of review Common variants in the gene that encodes the transcription factor 7-like 2
(TCF7L2) have been strongly associated with type 2 diabetes. This highly reproducible association
may uncover novel mechanisms of glycemic pathophysiology. Recent findings The initial ... Cited by 36 - Related articles - BL Direct - All 4 versions
M Ahlzén, LE Johansson, C Cervin, H Tornqvist, L … - … and Biophysical Research …, 2008 - Elsevier In vitro, insulin decreased TCF7L2 mRNA expression. This effect was attenuated in cells incubated
with the free fatty acids palmitate or oleate. In vivo, we found significantly higher expression in
SAT from more insulin resistant subjects. No correlations between TCF7L2 mRNA ... Cited by 6 - Related articles - All 3 versions
C Marzi, C Huth, M Kolz, H Grallert, C … - … and metabolic research …, 2007 - ncbi.nlm.nih.gov Recently, significant associations between common variants of the transcription factor 7-like
2 gene ( TCF7L2) and type 2 diabetes have been reported. This study was designed to replicate
the reported associations of the two highly correlated (r (2)=0.86) TCF7L2 single ... Cited by 31 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org YC Chang, TJ Chang, YD Jiang, SS Kuo, KC Lee, KC … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—The previously reported SNPs rs7903146 T- and rs12255372 T-alleles of the TCF7L2
gene were rare and were not associated with type 2 diabetes in a Chinese population, which
may attribute to the low frequencies of these two SNPs. SNP rs290487 located in an LD ... Cited by 43 - Related articles - BL Direct - All 4 versions
- ►endojournals.org L Wegner, MS Hussain, K Pilgaard, T Hansen, … - Journal of Clinical …, 2008 - Endocrine Soc Results: Elderly T-allele carriers had decreased plasma insulin responses and lower disposition
index, whereas insulinogenic index was similar between genotype groups. Elderly nondiabetic
T-allele carriers had increased peripheral insulin sensitivity (P = 0.03). Young T-allele ... Cited by 11 - Related articles - All 3 versions
J Munoz, KH Lok, BA Gower, JR Fernandez, GR Hunter … - Diabetes, 2006 - Am Diabetes Assoc Recently, the transcription factor 7-like 2 (TCF7L2) gene on chromosome 10q25.2 has been
linked with type 2 diabetes among Caucasians, with disease associations noted for single nucleotide
polymorphisms (SNPs) rs12255372 and rs7903146. To investigate mechanisms by which ... Cited by 53 - Related articles - BL Direct - All 5 versions
