JW Calvert, S Gundewar, S Jha, JJM Greer, WH … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Clinical studies have reported that metformin reduces cardiovascular end points
of type 2 diabetic subjects by actions that cannot solely be attributed to glucose-lowering
effects. The therapeutic effects of metformin have been reported to be mediated by its ... Cited by 31 - Related articles - BL Direct - All 4 versions
- ►nih.gov JT Hwang, DY Kwon, OJ Park, MS Kim - Genes & Nutrition, 2008 - Springer Abstract Resveratrol, one of polyphenols derived from red wine, has been shown to protect against
cell death, possibly through the association with several signaling pathways. Currently numerous
studies indicate that car- diovascular diseases are linked to the release of intracellular ... Cited by 14 - Related articles - BL Direct - All 4 versions
S Gundewar, JW Calvert, S Jha, I Toedt-Pingel, S … - Circulation …, 2009 - Am Heart Assoc Clinical studies have reported that the widely used antihyperglycemic drug metformin significantly
reduces cardiac risk factors and improves clinical outcomes in patients with heart failure. The
mechanisms by which metformin exerts these cardioprotective effects remain unclear and ... Cited by 8 - Related articles - All 6 versions
AS Kim, EJ Miller, LH Young - Acta Physiologica, 2009 - ingentaconnect.com Over the past decade, AMP-activated protein kinase (AMPK) has emerged as an important intracellular
signalling pathway in the heart. Activated AMPK stimulates the production of ATP by regulating
key steps in both glucose and fatty acid metabolism. It has an inhibitory effect on cardiac ... Cited by 3 - Related articles
- ►cardiovascres.org … , P Puthanveetil, F Wang, MS Kim, S … - Cardiovascular …, 2009 - cardiovascres.oxfordjournals.org Methods and results: Cardiomyocytes were incubated with DEX, MET, or TNF- for varying durations
(0–12 h). TNF- -induced cell damage was evaluated by measuring caspase-3 activity and Hoechst
staining. Protein and gene estimation techniques were employed to determine the ... Cited by 3 - Related articles - All 5 versions
D An, G Kewalramani, JKY Chan, D Qi, S Ghosh, T … - Diabetologia, 2006 - Springer Page 1. ARTICLE Metformin influences cardiomyocyte cell death by pathways that are
dependent and independent of caspase-3 D. An & G. Kewalramani & JKY Chan & D. Qi
& S. Ghosh & T. Pulinilkunnil & A. Abrahani & SM Innis & B. Rodrigues ... Cited by 22 - Related articles - BL Direct - All 3 versions
RJ Legtenberg, RJF Houston, B Oeseburg … - Hormone and …, 2002 - thieme-connect.com The biguanide, metformin, is widely used for the treatment of type 2 diabetes mellitus. In the recently
published United Kingdom Prospective Diabetes Study (UKPDS), it was shown that the use of
metformin was associated with a reduction of macrovascular complications compared to ... Cited by 11 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org Y Zhang, TS Lee, EM Kolb, K Sun, X Lu, FM … - … , and vascular biology, 2006 - Am Heart Assoc Methods and Results— By using flow channels with cultured ECs, AMPK Thr172 phosphorylation
was increased with changes of flow rate or pulsatility. The activity of LKB1, the upstream kinase
of AMPK, and the phosphorylation of eNOS at Ser1179 were concomitant with AMPK ... Cited by 46 - Related articles - All 11 versions
[CITATION] Ca 2+/Calmodulin-dependant kinase kinase beta (CaMKKβ) contribuites to AMPK …
