- ►diabetesjournals.org V Kolavennu, L Zeng, H Peng, Y Wang, FR Danesh - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—RhoA, a small GTPase protein, and its immediate downstream target, Rho kinase
(ROCK), control a wide variety of signal transduction pathways. Recent studies have shown that
fasudil, a selective ROCK inhibitor, may play a pivotal role in a number of pathological ... Cited by 17 - Related articles - BL Direct - All 4 versions
- ►endocrinology-journals.org Y Kikuchi, M Yamada, T Imakiire, T … - Journal of …, 2007 - Soc Endocrinology Fasudil, a Rho-kinase inhibitor, may improve insulin signaling. However, its long-term effect on
metabolic abnormalities and its preventive effect on diabetic nephropathy are still unknown. We
assessed these effects of fasudil in insulin-resistant diabetic rats, comparing them with ... Cited by 16 - Related articles - BL Direct - All 4 versions
F Peng, D Wu, B Gao, AJ Ingram, B Zhang, K … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Glucose led to RhoA and downstream Rho-kinase activation. Mannitol was without
effect. Activity of the transcription factor AP-1, increased in diabetic MCs and kidneys, is important
in the profibrotic effects of glucose, and this was dependent on Rho-kinase signaling. ... Cited by 10 - Related articles - All 4 versions
A Gojo, K Utsunomiya, K Taniguchi, T Yokota, S … - European journal of …, 2007 - Elsevier This study aimed to investigate the effect of the Rho-kinase inhibitor fasudil on the development
of diabetic nephropathy and clarify a contribution of the Rho/Rho-kinase pathway to the pathogenesis
of diabetic nephropathy. Diabetes was induced in male Sprague–Dawley rats with an ... Cited by 22 - Related articles - All 4 versions
- ►oxfordjournals.org HL Heerspink, T Greene, JB Lewis, I Raz, RD … - Nephrology Dialysis …, 2008 - ERA-EDTA Methods. A total of 149 patients with type 2 diabetes and an albumin:creatinine ratio (ACR) between
20 and 300 mg/g were randomized with equal allocation to either placebo, 200 mg of sulodexide
or 400 mg of sulodexide. The primary endpoint was the achievement, at 6 months, of ... Cited by 11 - Related articles - BL Direct - All 4 versions
F Ishibashi - Diabetes research and clinical practice, 2008 - Elsevier In proximal tubular epithelial cells (PTECs), depolymerization of actin by cofilin plays a crucial
role in maintaining polarity and function. Cofilin is inactivated when phosphorylated by
p-Lin-11/Isl-1/Mec-3 kinase (LIMK) to give p-cofilin. LIMK is phosphorylated by ... Cited by 2 - Related articles - All 7 versions
- ►diabetesjournals.org LA Bach - Diabetes, 2008 - Am Diabetes Assoc RhoA/ROCK has a number of functions in the kidney. RhoA/ROCK enhances Ca 2+ -dependent
vascular smooth muscle contraction, thereby modulating tone (2–4). The potent vasoconstrictor
angiotensin II (AngII) activates ROCK in smooth muscle cells. The ROCK inhibitors fasudil ... Cited by 2 - Related articles - BL Direct - All 3 versions
A Ustundag, A Tugrul, S Ustundag, N Sut, B … - Renal …, 2008 - informahealthcare.com Increasing evidence suggests that circulating aldosterone per se contributes directly to renal
and cardiovascular diseases. We sought to evaluate the effects of a three-month treatment with
25 mg spironolactone, an aldosterone receptor antagonist, on nephron function in 20 type ... Cited by 2 - Related articles - All 5 versions
H Iwasaki, R Okamoto, S Kato, K Konishi, H Mizutani, N … - Atherosclerosis, 2008 - Elsevier PAI-1 expression in BAEC was significantly increased in accordance with the concentration of
glucose in media from 5.7 mM to 23 mM. Stimulation with high glucose (23 mM) significantly
increased small GTPase RhoA activation. Pretreatment with a Rho-kinase inhibitor, ... Cited by 12 - Related articles - All 18 versions
MT Coughlan, JM Forbes, ME Cooper - Kidney International, 2007 - nature.com The biochemical process of advanced glycation appears to play a central role in the development
and progression of diabetic vascular complications. A number of strategies to influence this pathway
have been designed, one of which involves the putative advanced glycation end-product ( ... Cited by 13 - Related articles - BL Direct - All 3 versions
