Y Liu, N Niu, X Zhu, T Du, X Wang, D Chen, X Wu, HF … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Two novel SNPs (–46127T>C and +98560A>G) were associated with type 2 diabetes
(P = 0.018 and 0.036; for possession of minor allele, odds ratio [OR] 0.620 and 3.199, with dominant
model and correction for multiple comparisons). In SNP rs1882094 (+141G>T), the ... Cited by 1 - Related articles - BL Direct - All 4 versions
YM Cho, HD Shin, BL Park, JH Kim, KS Park, SY Kim, … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Dysfunction in mitochondrial oxidative phosphorylation plays a central
role in insulin resistance and type 2 diabetes. Nuclear respiratory factor 1 (NRF1) is a transcription
factor that acts on nuclear genes encoding respiratory subunits and components of the ... Cited by 5 - Related articles - BL Direct - All 4 versions
A Bhat, A Koul, E Rai, S Sharma, MK Dhar, RNK … - Human genetics, 2007 - Springer Abstract The recent observations that Peroxisome prolif- erator activated receptor gamma coactivator
1 alpha (PGC1A) is responsible for the induction of reactive oxy- gen species (ROS) detoxifying
agents and that ROS trig- gers insulin resistance, support the role that this gene could ... Cited by 6 - Related articles - All 7 versions
- ►nih.gov C Ling, S Del Guerra, R Lupi, T Rönn, C Granhall, H … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis Insulin secretion in pancreatic islets is dependent upon mitochondrial
function and production of ATP. The transcriptional coactivator peroxisome proliferator activated
receptor gamma coactivator-1 alpha (protein PGC- 1α; gene PPARGC1A) is a master ... Cited by 9 - Related articles - BL Direct - All 6 versions
- ►oxfordjournals.org [PDF] D Conklin, I Jonassen, R Aasland, WR Taylor - Bioinformatics, 2002 - Oxford Univ Press ABSTRACT Motivation: Gene expression is dependent on two main types of signals; one involving
transcription factors which initiates gene transcription, and another which regulates the translation
of a nascent mRNA. These post- transcriptional events play an important yet incompletely ... Cited by 9 - Related articles - BL Direct - All 7 versions
GJ Wang, P Yang, HG Xie - Pharmacogenomics, 2006 - Future Medicine Over the past few decades, in particular after the completion of the Human Genome Project, there
has been an explosion of information regarding the study of genomic structure–function
relationships. This advances better understanding of human biodiversity or individual ... Cited by 9 - Related articles - All 4 versions
S Zhu, Y Liu, X Wang, X Wu, X Zhu, J Li, J Ma, HF … - Diabetes Research and …, 2009 - Elsevier The peroxisome proliferator-activated receptor-γ coactivator-1α (PPARGC1A) is a transcriptional
factor that regulates the genes involved in energy metabolism. Single nucleotide polymorphisms
(SNPs) in the PPARGC1A gene have been conflictingly reported to be associated with ... Related articles - All 2 versions
[CITATION] A common Gly482Ser polymorphism of PGC-1 is associated with type 2 diabetes …
LM t Hart, T Hansen, I Rietveld, JM Dekker, G Nijpels, G … - Diabetes, 2005 - Am Diabetes Assoc Previously, we have shown that a mutation in the mitochondrial DNA–encoded tRNA
Leu(UUR) gene is associated with type 2 diabetes. One of the consequences of this mutation
is a reduced aminoacylation of tRNA Leu(UUR) . In this study, we have examined ... Cited by 13 - Related articles - All 8 versions
CG Östenson, P Båvenholm, S Efendic - Läkartidningen, År, 2004 - ltarkiv.lakartidningen.se ❙❙ Typ 2-diabetes kännetecknas av såväl kronisk hyperglyk- emi som andra metabola rubbningar
i bl a lipidomsättning och hemostas. Hyperglykemin utvecklas oftast på grund av nedsatt insulinkänslighet
(insulinresistens) och en otillräck- lig insulinsekretion [1, 2]. Insulinresistens förekommer ... Related articles - View as HTML - All 6 versions
