- ►diabetesjournals.org C Tikellis, K Bialkowski, J Pete, K Sheehy, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— Induction of diabetes in wild-type mice was associated with a
reduction in renal ACE2 expression and decreased Ang 1–7. In diabetic mice
receiving MLN-4760 and in ACE2 KO mice, diabetes-associated albuminuria was ... Cited by 9 - Related articles - BL Direct - All 5 versions
S Mizuiri, H Hemmi, M Arita, Y Ohashi, Y … - American Journal of Kidney Diseases, 2008 - Elsevier BACKGROUND: Angiotensin-converting enzyme (ACE) 2 (ACE2) is expressed mainly in
the heart and kidney and forms angiotensin-1-7 from angiotensin II. ACE2 might
act in a counterregulatory manner to ACE. There is little information about ... Cited by 12 - Related articles - All 21 versions
A Koitka, ME Cooper, MC Thomas, C Tikellis - Clinical and Experimental Pharmacology and …, 2008 - pt.wkhealth.com 1. Angiotensin converting enzyme 2 (ACE2) is an important homeostatic component
of the renin angiotensin system (RAS). ACE2 both degrades the vasoconstrictor,
angiotensin II and generates the potent vasodilator peptide, angiotensin ... Cited by 2 - Related articles - BL Direct - All 5 versions
H Ji, S Menini, W Zheng, C Pesce, X Wu, K … - Experimental Physiology, 2008 - Physiological Soc 17β-Oestradiol (E 2 )-mediated inhibition of angiotensin-converting enzyme
(ACE) protects the E 2 -replete kidney from the progression of hypertensive
renal disease. Angiotensin-converting enzyme 2 (ACE2), a homologue of ACE, ... Cited by 4 - Related articles - BL Direct - All 9 versions
- ►amjpathol.org DW Wong, GY Oudit, H Reich, Z Kassiri, J … - American Journal of Pathology, 2007 - ASIP Activation of the renin-angiotensin system (RAS) and the generation of
angiotensin (Ang) II play an important role in the pathogenesis of diabetic
nephropathy and blockade of the RAS in both experimental and clinical ... Cited by 37 - Related articles - BL Direct - All 8 versions
DJ Leehey, AK Singh, JP Bast, P Sethupathi, … - Translational Research, 2008 - Elsevier Substantial evidence suggests that the intrarenal renin-angiotensin system (RAS)
plays a role in the pathogenesis of diabetic nephropathy. Although the
glomerular RAS is activated in the streptozotocin (STZ)-diabetic rat, the ... Cited by 4 - Related articles - All 13 versions
MJ Soler, J Wysocki, M Ye, J Lloveras, Y … - Kidney International, 2007 - nature.com Angiotensin converting enzyme 2 (ACE2) is localized to the glomerular epithelial
cells. Since ACE2 promotes the degradation of angiotensin II, a decrease in ACE2
activity could lead to the development of glomerular injury. We gave a ... Cited by 30 - Related articles - BL Direct - All 3 versions
G Wang, FMM Lai, KB Lai, KM Chow, CHB … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis The interplay of ACE and type 2 ACE (ACE2) has been
recognised as playing an important role in the tissue renin–angiotensin system
within the kidney. In the present study, we measured urinary mRNA ... Cited by 6 - Related articles - BL Direct - All 2 versions
Y Shao, M He, L Zhou, T Yao, Y Huang, L Lu - Acta Pharmacologica Sinica, 2008 - nature.com Streptozotocin (STZ) injection-induced diabetic rats were used in the
experiment. The animals were divided into 3 groups: (1) control; (2) STZ-induced
diabetes; and (3) STZ-induced diabetes with chronic Ang (1–7) treatment ... Cited by 6 - Related articles - All 4 versions
- ►problemsinanes.com D Batlle, MJ Soler, J Wysocki - Current Opinion in Nephrology and Hypertension, 2008 - journals.lww.com Introduction The renin–angiotensin (Ang) system (RAS) in its classical
conception consists of a cascade of enzymatic reactions primarily aimed to the
formation of Ang II – the best- studied and most active peptide within ... Cited by 7 - Related articles - BL Direct - All 13 versions
