- ►diabetesjournals.org H Erlich, AM Valdes, J Noble, JA Carlson, M Varney, P … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—A number of susceptible, neutral, and protective DR-DQ haplotypes have been
identified, and a statistically significant hierarchy of type 1 diabetes risk has been
established. The most susceptible haplotypes are the DRB1*0301-DQA1*0501-DQB1* ... Cited by 32 - Related articles - BL Direct - All 7 versions
G Thomson, AM Valdes, JA Noble, I Kockum, MN … - Tissue …, 2007 - interscience.wiley.com The direct involvement of the human leukocyte antigen class II DR-DQ genes in type 1 diabetes
(T1D) is well established, and these genes display a complex hierarchy of risk effects at the genotype
and haplotype levels. We investigated, using data from 38 studies, whether the DR-DQ ... Cited by 30 - Related articles - All 5 versions
- ►nih.gov S Nejentsev, JMM Howson, NM Walker, J Szeszko, SF … - Nature, 2007 - nature.com Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian
Building, University Road, Leicester LE1 7RH, UK. ... Juvenile Diabetes Research
Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of ... Cited by 86 - Related articles - BL Direct - All 7 versions
AM Valdes, HA Erlich, JA Noble - Human immunology, 2005 - Elsevier Alleles of human leukocyte antigen (HLA) class II genes are well known to affect susceptibility
to type 1 diabetes (T1D), but less is known about the contribution of HLA class I alleles to T1D
susceptibility. In this study, molecular genotyping was performed at the HLA-B and HLA-C ... Cited by 36 - Related articles - All 3 versions
- ►diabetesjournals.org TA Aly, EE Baschal, MM Jahromi, MS Fernando, SR … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—We found evidence for an association with type 1A diabetes (rs1233478, P = 1.6
× 10 −23 , allelic odds ratio 2.0) in the UBD/MAS1L region, telomeric of the classic MHC. We
also observed over 99% conservation for up to 9 million nucleotides between ... Cited by 10 - Related articles - BL Direct - All 3 versions
TA Aly, A Ide, MM Jahromi, JM Barker, … - Proceedings of the …, 2006 - National Acad Sciences Type 1A diabetes (T1D) is an autoimmune disorder the risk of which is increased by specific
HLA DR/DQ alleles [eg, DRB1*03-DQB1*0201 (DR3) or DRB1*04-DQB1*0302 (DR4)]. The genotype
associated with the highest risk for T1D is the DR3/4-DQ8 (DQ8 is DQA1*0301, ... Cited by 54 - Related articles - BL Direct - All 9 versions
R Hermann, AP Laine, R Veijola, T Vahlberg, S Simell, … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: The aim of this study was to explore the contribution of genetic factors
to the emer- gence of beta-cell-specific humoral autoimmunity. Subjects and methods: We analysed
the effect of HLA class II, in- sulin (INS; −23 HphI variant) and cytotoxic T-lymphocyte- ... Cited by 18 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] BA Lie, KS Rønningen, HE Akselsen, E Thorsby, … - The American Journal of …, 2000 - Elsevier It is widely believed that, if a genetic marker shows a transmission distortion in patients by the
transmission/disequilibrium test (TDT), then a transmission distortion in healthy siblings would
be seen in the opposite direction. This is also the case in a complex disease. ... Cited by 19 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org M Rodacki, B Svoren, V Butty, W Besse, L Laffel, C … - Diabetes, 2007 - Am Diabetes Assoc Evidence from animal models suggests that natural killer (NK) cells can be important players
in the development of type 1 diabetes, although data in humans are still sparse. We studied the
frequency and activation state of blood NK cells at different stages of human type 1 ... Cited by 20 - Related articles - BL Direct - All 6 versions
JA Noble, A Martin, AM Valdes, JA Lane, A Galgani, A … - Human Immunology, 2008 - Elsevier Patients with high-risk human leukocyte antigen (HLA)-DR-DQ genotypes for type 1 diabetes
(T1D) were compared with HLA-matched controls to evaluate T1D risk for other HLA loci, including
HLA-A, -B, -Cw, and DPB1. Patients (n = 133) with high-risk genotypes (DR3/DR3, ... Cited by 4 - Related articles - All 3 versions
