JB McAteer, S Prudente, S Bacci, HN Lyon, JN … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Functional studies suggest that the nonsynonymous K121Q polymorphism in the
ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) may confer susceptibility
to insulin resistance; genetic evidence on its effect on type 2 diabetes, however, has been ... Related articles - All 2 versions
- ►diabetesjournals.org [PDF] JB McAteer, S Prudente, S Bacci, HN Lyon, JN … - Diabetes, 2007 - Am Diabetes Assoc From the 1 Diabetes Unit and Center for Human Genetic Research, Massachusetts General
Hospital, Boston, Massachusetts; 2 the Program in Medical and Population Genetics, Broad Institute
of Harvard and MIT, Cambridge, Massachusetts; 3 Research Unit of Diabetes and ... Cited by 22 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org ES Stolerman, AK Manning, JB McAteer, J Dupuis, CS … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—The Q allele of K121Q (rs1044498) was associated with increased fasting plasma
glucose (FPG), A1C, fasting insulin, and insulin resistance by homeostasis model assessment
(HOMA-IR; all P = 0.01–0.006). Two noncoding SNPs (rs7775386 and rs7773477) ... Cited by 7 - Related articles - All 5 versions
- ►diabetesjournals.org [PDF] ES Stolerman, AK Manning, JB McAteer, J Dupuis, CS … - Diabetes, 2008 - Am Diabetes Assoc Page 1. ENPP1 POLYMORPHISMS AND GLYCEMIC TRAITS HAPLOTYPE STRUCTURE
OF THE ENPP1 GENE AND NOMINAL ASSOCIATION OF THE K121Q POLYMORPHISM
WITH GLYCEMIC TRAITS IN THE FRAMINGHAM HEART STUDY ... Cited by 6 - Related articles - All 2 versions
AF Moore, KA Jablonski, CC Mason, JB … - Journal of Clinical …, 2009 - Endocrine Soc Results: Fasting glucose and glycated hemoglobin were higher in QQ homozygotes at baseline
(P < 0.001 for both). There was a significant interaction between genotype at rs1044498 and
intervention under the dominant model (P = 0.03). In analyses stratified by treatment arm, ... Cited by 3 - Related articles - All 3 versions
Y El Achhab, D Meyre, N Bouatia-Naji, M Berraho, M … - Diabetes and Metabolism, 2009 - Elsevier The ectonucleotide pyrophosphatase/phosphodiesterase 1 enzyme (ENPP1), which downregulates
insulin signaling by inhibiting insulin-receptor tyrosine kinase activity, is encoded by the ENPP1
gene. A common functional ENPP1 K121Q polymorphism has been suggested to ... Related articles - All 2 versions
S Bacci, S De Cosmo, S Prudente, V … - Current Opinion in Clinical …, 2007 - journals.lww.com Purpose of review: Insulin resistance plays a significant role in both morbidity and mortality of
the general population. Understanding the molecular mechanisms of insulin resistance would
help the identification of at-risk individuals in the presymptomatic stage, and the discovery ... Cited by 10 - Related articles - BL Direct - All 4 versions
A Morandi, L Pinelli, A Petrone, V Vatin, R Buzzetti, P … - 2008 - nature.com Ectonucleotide Pyrophosphatase Phosphodiesterase 1 (ENPP1) downregulates insulin signaling
by inhibiting the insulin receptor's tyrosine-kinase. K121Q and other ENPP1 single-nucleotide
polymorphisms (SNPs), IVS20delT-11 and A/G+1044TGA, have been previously ... Related articles - All 3 versions
- ►diabetesjournals.org KL Keene, JC Mychaleckyj, SG Smith, TS Leak, PS … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Variants in the ectonucleotide pyrophosphatase/phosphodiesterase 1
(ENPP1) gene have shown positive associations with diabetes and related phenotypes, including
insulin resistance, metabolic syndrome, and type 1 diabetic nephropathy. Additionally, ... Cited by 9 - Related articles - BL Direct - All 3 versions
