- ►diabetesjournals.org M Chari, CKL Lam, PYT Wang, TKT Lam - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—We performed intracerebroventricular (ICV)
administration of lactate to enhance central lactate metabolism in 1)
early-onset streptozotocin-induced uncontrolled diabetic rodents, 2) ... Cited by 6 - Related articles - BL Direct - All 3 versions
- ►physiology.org CKL Lam, M Chari, PYT Wang, TKT Lam - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc The central nervous system regulates food intake (FI) and body weight (BW), but
the associated mechanisms remain to be elucidated. Here we report that central
injections of lactate reduced FI and BW in rodents. Inhibition of central ... Cited by 3 - Related articles - All 3 versions
R Ross, PYT Wang, M Chari, CKL Lam, L Caspi, … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—To examine whether hypothalamic protein kinase C
(PKC) mediates the ability of central nervous system lipids to activate K ATP
channels and regulate glucose production in normal rodents, we first ... Cited by 4 - Related articles - All 4 versions
A Kokorovic, GW Cheung, L Rossetti, TK Lam … - J Cell Mol Med - interscience.wiley.com Emerging studies indicate that hypothalamic hormonal signaling pathways and
nutrient metabolism regulate glucose homeostasis in rodents. Although
hypothalamic lactate-sensing mechanisms have been described to lower ... Cited by 1 - Related articles - All 2 versions
L Caspi, PY Wang, TK Lam - Cell metabolism, 2007 - ncbi.nlm.nih.gov Recent work has cast a spotlight on the brain as a nutrient-sensing organ that
regulates the body's metabolic processes. Here we discuss the physiological and
molecular mechanisms of brain lipid sensing and compare these mechanisms to ... Cited by 9 - Related articles - All 2 versions
- ►nih.gov MV Chakravarthy, Y Zhu, L Yin, T Coleman, … - The Journal of Lipid Research, 2009 - ASBMB Obesity promotes insulin resistance and chronic inflammation. Disrupting any of
several distinct steps in lipid synthesis decreases adiposity, but it is unclear
if this approach coordinately corrects the environment that propagates ... Related articles - All 6 versions
CKL Lam, M Chari, TKT Lam - Physiology, 2009 - Am Physiological Soc The past decade has hosted a remarkable surge in research dedicated to the
central control of homeostatic mechanisms. Evidence indicates that the brain, in
particular the hypothalamus, directly senses hormones and nutrients to ... Cited by 1 - Related articles - All 3 versions
RW Gelling, GJ Morton, CD Morrison, KD … - Cell Metabolism, 2006 - Elsevier To investigate the role of brain insulin action in the pathogenesis and
treatment of diabetes, we asked whether neuronal insulin signaling is required
for glucose-lowering during insulin treatment of diabetes. Hypothalamic ... Cited by 33 - Related articles - All 8 versions
- ►cell.com AC Könner, R Janoschek, L Plum, SD Jordan, … - Cell metabolism, 2007 - Elsevier Insulin action in the central nervous system regulates energy homeostasis and
glucose metabolism. To define the insulin-responsive neurons that mediate these
effects, we generated mice with selective inactivation of the insulin ... Cited by 34 - Related articles - All 5 versions
M Cesquini, GR Stoppa, PO Prada, AS Torsoni … - Life sciences, 2008 - Elsevier The hypothalamic AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase
(ACC) pathway is known to play an important role in the control of food intake
and energy expenditure. Here, we hypothesize that citrate, an intermediate ... Cited by 2 - Related articles - All 4 versions
