SC Martinez, K Tanabe, C Cras-Méneur, NA Abumrad, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Increasing fatty acid concentrations (100–400 μmol/l palmitate or oleate) led to early
Jun NH 2 -terminal kinase (JNK) activation that preceded induction of ER stress markers and
apoptosis. Foxo1 activity was increased with fatty acid administration and by ... Cited by 15 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] SC Martinez, K Tanabe, C Cras-Méneur, NA Abumrad, … - Diabetes, 2008 - Am Diabetes Assoc Page 1. Inhibition of Foxo1 Protects Pancreatic Islet ®-Cells Against Fatty Acid and ER-Stress
Induced Apoptosis Sara C. Martinez 1 , Katsuya Tanabe 1 , Corentin Cras-Méneur 1 , Nada
A. Abumrad 2 , Ernesto Bernal-Mizrachi 1 , M. Alan Permutt 1 ... Cited by 3 - Related articles - All 2 versions
E Bachar, Y Ariav, M Ketzinel-Gilad, E Cerasi, N … - PLoS One, 2009 - pubmedcentral.nih.gov We found that glucose amplifies palmitate-induced ER stress by increasing IRE1α protein levels
and activating the JNK pathway, leading to increased β-cell apoptosis. Moreover, glucose increased
mTORC1 activity and its inhibition by rapamycin decreased β-cell apoptosis under ... Cited by 6 - Related articles - All 5 versions
- ►biologists.org DA Cunha, P Hekerman, L Ladriere, A Bazarra- … - Journal of cell …, 2008 - jcs.biologists.org Free fatty acids (FFA) cause apoptosis of pancreatic β-cells and might contribute to β-cell loss
in type 2 diabetes via the induction of endoplasmic reticulum (ER) stress. We studied here the
molecular mechanisms implicated in FFA-induced ER stress initiation and apoptosis in ... Cited by 23 - Related articles - All 5 versions
- ►physiology.org TT Goh, TM Mason, N Gupta, A So, TKT … - American Journal of …, 2007 - Am Physiological Soc We determined the effect of 48-h elevation of plasma free fatty acids (FFA) on insulin secretion
during hyperglycemic clamps in control female Wistar rats (group a) and in the following female
rat models of progressive -cell dysfunction: lean Zucker diabetic fatty (ZDF) rats, both wild- ... Cited by 18 - Related articles - BL Direct - All 5 versions
- ►jbc.org V Koshkin, FF Dai, CA Robson-Doucette, CB Chan, … - Journal of Biological …, 2008 - ASBMB Involvement of the mitochondrial permeability transition (MPT) pore in early stages of lipotoxic
stress in the pancreatic β-cell lines MIN6 and INS-1 was the focus of this study. Both long term
(indirect) and acute (direct) effects of fatty acid (FA) application on β-cell susceptibility to ... Cited by 10 - Related articles - All 4 versions
K Tanabe, Z Liu, S Patel, BW Doble, L Li, C Cras- … - PLoS Biol, 2008 - biology.plosjournals.org Despite treatment with agents that enhance β-cell function and insulin action, reduction in β-cell
mass is relentless in patients with insulin resistance and type 2 diabetes mellitus. Insulin resistance
is characterized by impaired signaling through the insulin/insulin receptor/insulin receptor ... Cited by 11 - Related articles - Cached - All 8 versions
- ►pnas.org L Rachdi, N Balcazar, F Osorio-Duque, L … - Proceedings of the …, 2008 - National Acad Sciences Regulation of pancreatic β cell mass and function is a major determinant for the development
of diabetes. Growth factors and nutrients are important regulators of β cell mass and
function. The signaling pathways by which these growth signals modulate these ... Cited by 12 - Related articles - All 6 versions
KD Jeffrey, EU Alejandro, DS Luciani, TB … - Proceedings of the …, 2008 - National Acad Sciences Obesity is a principal risk factor for type 2 diabetes, and elevated fatty acids reduce β-cell function
and survival. An unbiased proteomic screen was used to identify targets of palmitate in β-cell
death. The most significantly altered protein in both human islets and MIN6 β-cells treated ... Cited by 14 - Related articles - BL Direct - All 5 versions
JD Perkins - Liver transplantation: official publication of the …, 2006 - ncbi.nlm.nih.gov BACKGROUND: The use of steatotic livers is associated with increased primary nonfunction
in liver transplantation. To reduce the risk of liver injury, we applied a short-term combination
therapy of diet, exercise and drugs for 11 living-donor liver transplantation (LDLT) ... Cited by 5 - Related articles
