SL McGee, BJW van Denderen, KF Howlett, J Mollica, … - Diabetes, 2008 - Am Diabetes Assoc Type 2 diabetes currently affects ∼171 million people worldwide, and this figure is predicted
to rise to 366 million by 2030 (1). The pathogenesis of this disease involves insulin resistance
in peripheral tissues, particularly in skeletal muscle (2). Insulin-regulated GLUT4 is highly ... Cited by 22 - Related articles - BL Direct - All 3 versions
SL McGee, M Hargreaves - Frontiers in bioscience: a journal and virtual …, 2008 - ncbi.nlm.nih.gov The AMP-activated protein kinase (AMPK) is an energy sensing enzyme that once activated,
promotes energy production and limits energy utilisation to ensure cellular survival. In addition
to targeting numerous metabolic enzymes for this purpose, it is becoming apparent that ... Cited by 22 - Related articles
- ►physiology.org T Akimoto, P Li, Z Yan - American Journal of Physiology- Cell …, 2008 - Am Physiological Soc Real-time optical bioluminescence imaging is a powerful tool for studies of gene regulation in
living animals. To elucidate exercise-induced signaling/transcriptional control of the peroxisome
proliferator-activated receptor- coactivator-1 (Pgc-1 ) gene in skeletal muscle, we ... Cited by 10 - Related articles - All 5 versions
EA Richter, NB Ruderman - The Biochemical journal, 2009 - ncbi.nlm.nih.gov AMPK (AMP-activated protein kinase) is a phylogenetically conserved fuel-sensing enzyme that
is present in all mammalian cells. During exercise, it is activated in skeletal muscle in
humans, and at least in rodents, also in adipose tissue, liver and perhaps other organs by ... Cited by 12 - Related articles - All 3 versions
- ►physiology.org JAH Smith, M Collins, LA Grobler, CJ … - American Journal of …, 2007 - Am Physiological Soc In vitro binding assays have indicated that the exercise-induced increase in muscle GLUT4 is
preceded by increased binding of myocyte enhancer factor 2A (MEF2A) to its cis-element on
the Glut4 promoter. Because in vivo binding conditions are often not adequately ... Cited by 14 - Related articles - BL Direct - All 4 versions
- ►physiology.org JAH Smith, TA Kohn, AK Chetty, EO … - American Journal of …, 2008 - Am Physiological Soc The role of CaMK II in regulating GLUT4 expression in response to intermittent exercise was
investigated. Wistar rats completed 5 x 17-min bouts of swimming after receiving 5 mg/kg KN93
(a CaMK II inhibitor), KN92 (an analog of KN93 that does not inhibit CaMK II), or an ... Cited by 5 - Related articles - All 3 versions
NL Dzamko, JD Schertzer, J Ryall, R Steel, … - The Journal of …, 2008 - Physiological Soc The activation of AMP-activated protein kinase (AMPK) and phosphorylation/inhibition of
acetyl-CoA carboxylase 2 (ACC2) is believed to be the principal pathway regulating fatty acid
oxidation. However, during muscle contraction/exercise AMPK activity and ACC ... Cited by 13 - Related articles - All 5 versions
- ►nih.gov J Backs, T Backs, S Bezprozvannaya, TA … - Molecular and Cellular …, 2008 - Am Soc Microbiol Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates histone deacetylase
4 (HDAC4), a class IIa HDAC, resulting in the cytosolic accumulation of HDAC4 and the derepression
of the transcription factor myocyte enhancer factor 2. Phosphorylation by CaMKII requires ... Cited by 14 - Related articles - BL Direct - All 6 versions
PF Mount, N Lane, S Venkatesan, GR Steinberg, SA … - Atherosclerosis, 2008 - Elsevier Endothelial cell lipotoxicity mediated by accumulation of free fatty acids is an early event in the
pathogenesis of atherosclerosis. The energy-sensor AMP-activated protein kinase (AMPK) is
a key regulator of endothelial cell lipid metabolism. To test the hypothesis that bradykinin ( ... Cited by 7 - Related articles - All 21 versions
