J Chen, G Saxena, IN Mungrue, AJ Lusis, A Shalev - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Incubation of INS-1 cells at 25 mmol/l glucose for 24 h led to an 18-fold increase
in TXNIP protein, as assessed by immunoblotting. This was accompanied by increased
apoptosis, as demonstrated by a 12-fold induction of cleaved caspase-3. Overexpression ... Cited by 27 - Related articles - BL Direct - All 3 versions
- ►fasebj.org J Chen, ST Hui, FM Couto, IN Mungrue, DB Davis, AD … - The FASEB Journal, 2008 - FASEB Pancreatic beta-cell loss through apoptosis represents a key factor in the pathogenesis of
diabetes; however, no effective approaches to block this process and preserve endogenous
beta-cell mass are currently available. To study the role of thioredoxin-interacting protein ( ... Cited by 11 - Related articles - All 5 versions
WA Chutkow, P Patwari, J Yoshioka, RT Lee - Journal of Biological Chemistry, 2008 - ASBMB Thioredoxin-interacting protein (Txnip) has been recently described as a possible link between
cellular redox state and metabolism; Txnip binds thioredoxin and inhibits its disulfide reductase
activity in vitro, while a naturally occurring strain of Txnip-deficient mice has ... Cited by 14 - Related articles - All 4 versions
H Parikh, E Carlsson, WA Chutkow, LE … - PLoS …, 2007 - medicine.plosjournals.org We combined human insulin/glucose clamp physiological studies with genome-wide expression
profiling to identify thioredoxin interacting protein (TXNIP) as a gene whose expression is powerfully
suppressed by insulin yet stimulated by glucose. In healthy individuals, its expression ... Cited by 35 - Related articles - Cached - All 15 versions
- ►diabetesjournals.org JA Corbett - Diabetes, 2008 - Am Diabetes Assoc The oxidation of glucose is required for the secretion of insulin by pancreatic β-cells. The product
of this oxidation, ATP, stimulates the closure of potassium channels and calcium-dependent
exocytosis of insulin. This system is beautifully regulated such that the precise amount of ... Cited by 5 - Related articles - BL Direct - All 3 versions
- ►endojournals.org AH Minn, C Hafele, A Shalev - Endocrinology, 2005 - Endocrine Soc Recently, we identified thioredoxin-interacting protein (TXNIP) as the most dramatically
glucose-induced gene in our human islet microarray study. TXNIP is a regulator of the cellular
redox state, but its role in pancreatic ß-cells and the mechanism of its regulation by ... Cited by 75 - Related articles - All 9 versions
P Patwari, LJ Higgins, WA Chutkow, J Yoshioka, RT … - Journal of Biological …, 2006 - ASBMB The thioredoxin system plays an important role in maintaining a reducing environment in the
cell. Recently, several thioredoxin binding partners have been identified and proposed to mediate
aspects of redox signaling, but the significance of these interactions is unclear in part due ... Cited by 38 - Related articles - BL Direct - All 12 versions
STY Hui, AM Andres, AK Miller, NJ … - Proceedings of the …, 2008 - National Acad Sciences Thioredoxin-interacting protein (Txnip) inhibits thioredoxin NADPH-dependent reduction of protein
disulfides. Total Txnip knockout (TKO) mice adapted inappropriately to prolonged fasting by shifting
fuel dependence of skeletal muscle and heart from fat and ketone bodies to glucose. TKO ... Cited by 16 - Related articles - BL Direct - All 8 versions
J Chen, FM Couto, AH Minn, A Shalev - Biochemical and Biophysical Research …, 2006 - Elsevier Exenatide (Ex-4) is a novel anti-diabetic drug that stimulates insulin secretion and enhances
β-cell mass, but the mechanisms involved are not fully understood. We found that Ex-4 protects
INS-1 β-cells against oxidative stress-induced apoptosis (TUNEL) and also reduces ... Cited by 26 - Related articles - All 6 versions
TY Hui, SS Sheth, JM Diffley, DW Potter, AJ Lusis, … - Journal of Biological …, 2004 - ASBMB Thioredoxin-interacting protein (Txnip) is a ubiquitous protein that binds with high affinity to thioredoxin
and inhibits its ability to reduce sulfhydryl groups via NADPH oxidation. HcB-19 mice contain
a nonsense mutation in Txnip that eliminates its expression. Unlike normal animals, ... Cited by 53 - Related articles - BL Direct - All 9 versions
