- ►diabetesjournals.org M Fraenkel, M Ketzinel-Gilad, Y Ariav, O … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Unexpectedly, rapamycin worsened hyperglycemia in diabetic P. obesus
without affecting glycemia in normoglycemic controls. There was a 10-fold
increase of serum insulin in diabetic P. obesus compared with controls; ... Cited by 20 - Related articles - BL Direct - All 4 versions
- ►pnas.org L Rachdi, N Balcazar, F Osorio-Duque, L … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences Regulation of pancreatic β cell mass and function is a major determinant for
the development of diabetes. Growth factors and nutrients are important
regulators of β cell mass and function. The signaling pathways by which ... Cited by 12 - Related articles - All 6 versions
G Leibowitz, E Cerasi, M Ketzinel-Gilad - Diabetes, Obesity and Metabolism, 2008 - interscience.wiley.com Mammalian target of rapamycin (mTOR) is an important nutrient sensor that plays
a critical role in cellular metabolism, growth, proliferation and apoptosis and
in the cellular response to oxidative stress. In addition, mTOR–raptor ... Cited by 4 - Related articles - All 3 versions
- ►asnjournals.org S Di Paolo, A Teutonico, D Leogrande, C … - Journal of the American Society of Nephrology, 2006 - Am Soc Nephrol Overactivation of the mammalian target of rapamycin (mTOR) branch downstream of
the phosphatidylinositol 3-kinase–AKT pathway critically modulates insulin and
growth factor signaling by insulin receptor substrates (IRS). On the basis ... Cited by 23 - Related articles - All 6 versions
- ►diabetesjournals.org N Kaiser, R Nesher, MY Donath, M Fraenkel, V … - Diabetes, 2005 - Am Diabetes Assoc Type 2 diabetes is characterized by insulin resistance and progressive ß-cell
failure. Deficient insulin secretion, with increased proportions of insulin
precursor molecules, is a common feature of type 2 diabetes; this could ... Cited by 26 - Related articles - BL Direct - All 6 versions
CT Bussiere, JRT Lakey, AMJ Shapiro, GS … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis The Edmonton Protocol for islet trans- plantation has
provided hope for type 1 diabetic patients. However, this protocol requires
lifelong immunosuppres- sion, specifically sirolimus, a cellular ... Cited by 29 - Related articles - BL Direct - All 4 versions
- ►nih.gov Y Shigeyama, T Kobayashi, Y Kido, N … - Molecular and Cellular Biology, 2008 - Am Soc Microbiol Recent studies have demonstrated the importance of insulin or insulin-like
growth factor 1 (IGF-1) for regulation of pancreatic β-cell mass. Given the
role of tuberous sclerosis complex 2 (TSC2) as an upstream molecule of mTOR ... Cited by 9 - Related articles - BL Direct - All 7 versions
I Briaud, LM Dickson, MK Lingohr, JF … - Journal of Biological Chemistry, 2005 - ASBMB Regulation of insulin receptor substrate (IRS)-2 expression is critical to
β-cell survival, but the mechanisms that control this are complex and
undefined. Here in pancreatic β-cells (INS-1), chronic exposure (>8 h) to ... Cited by 44 - Related articles - All 5 versions
[CITATION] Immunotherapy with antibodies to protect beta cells in type I diabetic pancreas transplant …
