K Bouzakri, P Ribaux, A Tomas, G Parnaud, … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Protein kinase B/Akt plays a central role in β-cells, but little
is known regarding downstream Akt substrates in these cells. Recently, Rab
GTPase-activating protein AS160, a substrate of Akt, was shown to be ... Cited by 5 - Related articles - BL Direct - All 4 versions
B Yermen, A Tomas, PA Halban - Diabetes, 2007 - Am Diabetes Assoc We have previously shown that the Ca 2+ -dependent actin-severing protein
gelsolin plays an important role in regulated insulin secretion. The aim of this
study was to determine the role of gelsolin in β-cell survival as it has ... Cited by 7 - Related articles - BL Direct - All 6 versions
B Qian, H Wang, X Men, W Zhang, H Cai, S Xu … - Journal of Endocrinology, 2008 - Soc Endocrinology We found that TRB3, an endogenous inhibitor of Akt (PKB), is expressed in
pancreatic β-cells. The TRB3 expression is significantly increased in islets
isolated from hyperglycemic GK rats comparing with normal-glycemic ... Cited by 1 - Related articles - All 4 versions
- ►endojournals.org P Ribaux, JA Ehses, N Lin-Marq, F … - Endocrinology, 2007 - Endocrine Soc As we showed previously, the extracellular matrix (ECM) derived from rat bladder
carcinoma cells (804G-ECM) has positive effects on rat primary β-cell function
and survival in vitro. The aim of this study was to define β-cell genes ... Cited by 13 - Related articles - BL Direct - All 4 versions
DL Eizirik, ML Colli, F Ortis - Nature Reviews Endocrinology, 2009 - phx1.medscape.com Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with a strong
inflammatory component. The latest studies indicate that innate immunity and
inflammatory mediators have a much broader role in T1DM than initially ... Cited by 8 - Related articles - All 8 versions
M Lawrence, C Shao, L Duan, K McGlynn, … - Acta Physiologica, 2008 - interscience.wiley.com Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) activities are
modulated in a manner that reflects the secretory demand on β cells to
integrate long- and short-term nutrient sensing information. Our studies ... Cited by 11 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org D Li, X Yin, EJ Zmuda, CC Wolford, X Dong, … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—We used both the gain- and loss-of-function
approaches to test the effects of ATF3 on IRS2 gene expression. We also analyzed
the binding of ATF3 to the IRS2 promoter by chromatin immunoprecipitation ... Cited by 9 - Related articles - BL Direct - All 5 versions
- ►snu.ac.kr [PDF] ES Kang, D Han, J Park, TK Kwak, MA Oh, SA … - Experimental cell research, 2008 - Elsevier O-GlcNAc transferase (OGT)-mediated modification of protein Ser/Thr residues
with O-GlcNAc influences protein activity, similar to the effects of
phosphorylation. The anti-apoptotic Akt1 is both activated by ... Cited by 2 - Related articles - All 5 versions
