X Zhang, DCY Yeung, M Karpisek, D Stejskal, ZG Zhou … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— Serum FGF21 levels in overweight/obese subjects were significantly higher than
in lean individuals. Serum FGF21 correlated positively with adiposity, fasting insulin, and triglycerides
but negatively with HDL cholesterol, after adjusting for age and BMI. Logistic regression ... Cited by 27 - Related articles - BL Direct - All 4 versions
- ►endojournals.org I Dostalova, P Kavalkova, D Haluzikova, Z … - Journal of Clinical …, 2008 - Endocrine Soc Context: Fibroblast growth factor 19 (FGF19) and FGF21 are novel metabolic regulators that
improve insulin sensitivity and decrease adiposity in mice. However, little is known about the
nutritional regulation of these factors in humans. ... Objective: The objective of this study ... Cited by 11 - Related articles - All 3 versions
WW Chen, L Li, GY Yang, K Li, XY Qi, W Zhu, … - … clinical endocrinology & …, 2008 - ncbi.nlm.nih.gov 1: Exp Clin Endocrinol Diabetes. 2008 Jan;116(1):65-8. Epub 2007 Oct 9. Circulating
FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitus.
Chen WW, Li L, Yang GY, Li K, Qi XY, Zhu W, Tang Y, Liu H, Boden G. ... Cited by 15 - Related articles - BL Direct - All 3 versions
W Wente, AM Efanov, M Brenner, A Kharitonenkov, A … - Diabetes, 2006 - Am Diabetes Assoc Fibroblast growth factor-21 (FGF-21) is a recently discovered metabolic regulator. Here, we investigated
the effects of FGF-21 in the pancreatic β-cell. In rat islets and INS-1E cells, FGF-21 activated
extracellular signal–regulated kinase 1/2 and Akt signaling pathways. In islets isolated ... Cited by 57 - Related articles - BL Direct - All 4 versions
T Lundåsen, MC Hunt, LM Nilsson, S Sanyal, B … - … and biophysical research …, 2007 - Elsevier The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal
models of diabetes and obesity. Using quantitative RT-PCR, we here show that the hepatic gene
expression of FGF21 is regulated by the peroxisome proliferator-activated receptor alpha ( ... Cited by 35 - Related articles - All 4 versions
Y Izumiya, HA Bina, N Ouchi, Y Akasaki, A … - FEBS letters, 2008 - Elsevier Fibroblast growth factor-21 (FGF21) functions as a metabolic regulator. The FGF21 transcript
is reported to be abundantly expressed in liver, but little is known about the regulation of FGF21
expression in other tissues. In this study, we show that levels of FGF21 protein expression ... Cited by 15 - Related articles - All 4 versions
T Coskun, HA Bina, MA Schneider, JD Dunbar, CC Hu, … - Endocrinology, 2008 - Endocrine Soc Fibroblast growth factor 21 (FGF21) is a metabolic regulator that provides efficient and durable
glycemic and lipid control in various animal models. However, its potential to treat obe- sity, a
major health concern affecting over 30% of the popu- lation, has not been fully explored. ... Cited by 16 - Related articles - All 3 versions
C Gälman, T Lundåsen, A Kharitonenkov, HA Bina, M … - Cell Metabolism, 2008 - Elsevier FGF21 is a critical metabolic regulator, pivotal for fasting adaptation and directly regulated by
PPARα in rodents. However, the physiological role of FGF21 in man is not yet defined and was
investigated in our study. Serum FGF21 varied 250-fold among 76 healthy individuals ... Cited by 18 - Related articles - All 4 versions
- ►endojournals.org A Kharitonenkov, VJ Wroblewski, A Koester, YF Chen, … - Endocrinology, 2007 - Endocrine Soc Fibroblast growth factor (FGF)-21 has been recently characterized as a potent metabolic
regulator. Systemic administration of FGF-21 reduced plasma glucose and triglycerides to near
normal levels in genetically compromised diabetic rodents. Importantly, these effects were ... Cited by 60 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org ES Muise, B Azzolina, DW Kuo, M El-Sherbeini, Y … - Molecular Pharmacology, 2008 - ASPET Adipose tissue is a metabolically responsive endocrine organ that secretes a myriad of
adipokines. Antidiabetic drugs such as peroxisome proliferator-activated receptor (PPAR) agonists
target adipose tissue gene expression and correct hyperglycemia via whole-body insulin ... Cited by 11 - Related articles - All 3 versions
