- ►diabetesjournals.org MD McKenzie, EM Carrington, T Kaufmann, A Strasser, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Development and function of islets were not affected by loss of Bid, and Bid-deficient
islets were as susceptible as wild-type islets to cytotoxic stimuli that cause apoptosis via the mitochondrial
pathway. In contrast, Bid-deficient islets and those overexpressing antiapoptotic Bcl-2 ... Cited by 12 - Related articles - BL Direct - All 3 versions
MDMK BSc, EMC BSc, T Kaufmann, ASPD PhD, DCSH … - Am Diabetes Assoc Mark D. McKenzie BSc(Hons)1, Emma M. Carrington BSc(Hons)1, Thomas Kaufmann
PhD2, Andreas Strasser PhD2, David CS Huang PhD2, Thomas WH Kay PhD FRACP1, Janette
Allison PhD1, and Helen E. Thomas PhD1 ... 1 St. Vincent's Institute, 41 Victoria Parade, ... Related articles
AK Foulis - Novartis Foundation symposium, 2008 - ncbi.nlm.nih.gov In type 1 autoimmune diabetes there is a selective destruction of insulin-secreting beta cells.
Around the time of clinical presentation, insulitis, a chronic inflammatory infiltrate of the islets
affecting primarily insulin containing islets, is present in the majority of cases. The ... Cited by 2 - Related articles - All 2 versions
PJ Jost, S Grabow, D Gray, MD McKenzie, U Nachbur, … - BID - arapaho.nsuok.edu FAS (also called APO-1 and CD95) and its physiological ligand, FASL, regulate apoptosis of
unwanted or dangerous cells, func- tioning as a guardian against autoimmunity and cancer
develop- ment1–4. Distinct cell types differ in the mechanisms by which the 'death ... Cited by 4 - Related articles - View as HTML - All 5 versions
K Bouzakri, P Ribaux, A Tomas, G Parnaud, K … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Protein kinase B/Akt plays a central role in β-cells, but little is known regarding
downstream Akt substrates in these cells. Recently, Rab GTPase-activating protein AS160, a
substrate of Akt, was shown to be involved in insulin modulation of GLUT4 trafficking in ... Cited by 5 - Related articles - BL Direct - All 4 versions
B Yermen, A Tomas, PA Halban - Diabetes, 2007 - Am Diabetes Assoc We have previously shown that the Ca 2+ -dependent actin-severing protein gelsolin plays an
important role in regulated insulin secretion. The aim of this study was to determine the role of
gelsolin in β-cell survival as it has been shown to play a dual role in apoptosis in other ... Cited by 7 - Related articles - BL Direct - All 6 versions
E Estella, MD McKenzie, T Catterall, VR Sutton, PI Bird, … - Diabetes, 2006 - Am Diabetes Assoc Perforin-deficient NOD mice are protected from diabetes, suggesting that cytotoxic granule contents
of CD8 + T-cells have a significant role in killing β-cells. Despite this, cytotoxic granule effects
on human or mouse pancreatic islets have not been reported. We tested the susceptibility ... Cited by 14 - Related articles - BL Direct - All 4 versions
DL Eizirik, ML Colli, F Ortis - Nature Reviews Endocrinology, 2009 - phx1.medscape.com Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease with a strong inflammatory
component. The latest studies indicate that innate immunity and inflammatory mediators have
a much broader role in T1DM than initially assumed. Inflammation might contribute to ... Cited by 8 - Related articles - All 8 versions
M Lawrence, C Shao, L Duan, K McGlynn, MH … - Acta …, 2008 - interscience.wiley.com Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) activities are modulated in a
manner that reflects the secretory demand on β cells to integrate long- and short-term nutrient
sensing information. Our studies have focused on the mechanisms of ERK1/2 activation ... Cited by 11 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org D Li, X Yin, EJ Zmuda, CC Wolford, X Dong, MF White, … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—We used both the gain- and loss-of-function approaches
to test the effects of ATF3 on IRS2 gene expression. We also analyzed the binding of ATF3 to
the IRS2 promoter by chromatin immunoprecipitation assay and the transcription of the ... Cited by 9 - Related articles - BL Direct - All 5 versions
