- ►diabetesjournals.org G Fenalti, CS Hampe, Y Arafat, RHP Law, JP Banga, IR … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—The COOH-terminal region on GAD65 was the major autoantigenic site. B-cell epitopes
were distributed within two separate clusters around different faces of the COOH-terminal
domain. Inclusion of epitope sites in the pyridoxal phosphate–and NH 2 -terminal ... Cited by 8 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org SJ Kim, DG Jeong, SK Jeong, TS Yoon, SE Ryu - Diabetes, 2007 - Am Diabetes Assoc Insulinoma-associated protein-2 (IA-2) is a major autoantigen in type 1 diabetes that occurs through
autoimmune-mediated β-cell destruction. We present here the crystal structure of the protein
tyrosine phosphatase (PTP)-like domain of human IA-2. The structure reveals a canonical ... Cited by 7 - Related articles - BL Direct - All 6 versions
JCW PhD, AMB PhD, MJR PhD - Am Diabetes Assoc Gustavo Fenalti (BSc (Pharm)1, Christiane S. Hampe (PhD)2, Yasir Arafat (BSc (Eng)1, Ruby
HP Law (PhD)1, J. Paul Banga (PhD)3, Ian R. Mackay (MD)1, James C. Whisstock (PhD)1 ,,
Ashley M. Buckle (PhD)1, Merrill J. Rowley (PhD)1 ... 1Department of Biochemistry and ... Related articles
- ►pnas.org D Paus, G Winter - Proceedings of the National Academy of …, 2006 - National Acad Sciences Here we describe a method for mapping the binding of antibodies to the surface of a folded
antigen. We first created a panel of mutant antigens (β-lactamase) in which single surface-exposed
residues were mutated to cysteine. We then chemically tethered the cysteine residues to ... Cited by 11 - Related articles - BL Direct - All 10 versions
S Oak, LK Gilliam, M Landin-Olsson, C … - Proceedings of the …, 2008 - National Acad Sciences Autoantibodies to glutamate decarboxylase 65 (GAD65Ab) are commonly believed to be a major
characteristic for type 1 diabetes (T1D). We investigated the presence of GAD65Ab in healthy
individuals (n = 238) and first-degree relatives (FDRs) of T1D patients (n = 27) who tested ... Cited by 6 - Related articles - BL Direct - All 9 versions
G Fenalti, CS Hampe, KO'Connor, JP Banga, IR … - Molecular Immunology, 2007 - Elsevier Autoantibodies to the 65 kDa isoform of glutamate decarboxylase (GAD65) are associated with
type I diabetes and recognise highly conformational epitope(s) that remain to be defined. The
human recombinant Fab from mAb b96.11 inhibits binding of most GAD65 antibody ... Cited by 5 - Related articles - All 2 versions
CS Hampe, TR Hall, Å Ågren, O … - Clinical and …, 2007 - pubmedcentral.nih.gov We analysed the beta cell-specific autoimmunity reflected in autoantibodies to the smaller isoform
of glutamate decarboxylase (GAD65Ab) in the prediabetic period of GAD65Ab-positive healthy
adults who developed Type 2 diabetes (T2D) during a follow-up period of 10 years. We ... Cited by 6 - Related articles - BL Direct - All 6 versions
G Fenalti, RHP Law, AM Buckle, C Langendorf, K Tuck, … - Nature - imca.aps.anl.gov Gamma-aminobutyric acid (GABA) is synthesized by two isoforms of the pyridoxal
5¢-phosphate–dependent enzyme glutamic acid decarboxylase (GAD65 and GAD67). GAD67
is constitutively active and is responsible for basal GABA production. In contrast, GAD65, ... Cited by 19 - Related articles - View as HTML - BL Direct - All 4 versions
- ►endojournals.org CS Hampe, R Nalini, MR Maldonado, TR Hall, … - Journal of Clinical …, 2007 - Endocrine Soc Context: We previously characterized patients presenting with diabetic ketoacidosis prospectively
into four subgroups of ketosis-prone diabetes mellitus (KPDM), based on the presence or absence
of ß-cell autoimmunity (A+ or A–) and ß-cell functional reserve (B+ or B–). The A+B– ... Cited by 6 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org CJ Padoa, JP Banga, AM Madec, M Ziegler, M … - Diabetes, 2003 - Am Diabetes Assoc Autoantibodies to the 65-kDa isoform of GAD (GAD65Abs) are associated with type 1 diabetes
development, but the conformational nature of the GAD65Ab epitopes complicates the evaluation
of disease risk. Six GAD65-specific recombinant Fabs (rFabs) were cloned from ... Cited by 34 - Related articles - BL Direct - All 4 versions
