- ►diabetesjournals.org E Martinuzzi, G Novelli, M Scotto, P Blancou, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—CD8 + T-cell reactivities were less frequent at follow-up, as 28.6% of
responses tested positive at type 1 diabetes diagnosis vs. 13.2% after a median
of 11 months (P = 0.003). While GAD and IA-2 autoantibody (aAb) titers were ... Cited by 12 - Related articles - BL Direct - All 9 versions
E Martinuzzi, FA Lemonnier, C Boitard, R … - System, 1927 - interscience.wiley.com Type 1 diabetes (T1D) is a T cell–mediated autoimmune disease targeting
pancreatic β-cells. Despite this textbook definition, it is quite striking that
neither the diagnosis nor the therapy nor the follow-up of T1D "belong" to ... Cited by 2 - Related articles - All 4 versions
GG Pinkse, C Boitard, TI Tree, M Peakman, … - Annals of the New York Academy of Sciences, 2006 - ncbi.nlm.nih.gov Islet autoreactive CD8 T cells are plausible candidates for direct beta cell
toxicity in type 1 diabetes (T1DM). In 2005, cellular studies in the
pathogenesis of this disease have reached a new milestone. Autoreactive CD8 ... Cited by 8 - Related articles - BL Direct - All 3 versions
- ►inserm.fr [PDF] E Martinuzzi, M Scotto, E Enée, V Brezar, JA … - Journal of Immunological Methods, 2008 - Elsevier The identification of parameters maximizing detection sensitivity in ELISpot
assays is important to transfer this technology into the clinical setting for
identifying rare Ag-specific CD8 + T cells. We have therefore considered ... Cited by 3 - Related articles - All 6 versions
[CITATION] van EP: CD8 T-cell responses identify-cell autoimmunity in human type 1 diabetes
- ►diabetesjournals.org R Mallone, E Martinuzzi, P Blancou, G Novelli … - Diabetes, 2007 - Am Diabetes Assoc Despite the understanding that type 1 diabetes pathogenesis is mediated by
T-cells, detection of these rare lymphocytes remains largely elusive. Suitable
T-cell assays are highly needed, since they could offer preclinical ... Cited by 31 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org NE Standifer, Q Ouyang, C Panagiotopoulos, … - Diabetes, 2006 - Am Diabetes Assoc Cytotoxic T-lymphocytes (CTLs) are considered to be essential for β-cell
destruction in type 1 diabetes. However, few islet-associated peptides have been
demonstrated to activate autoreactive CTLs from type 1 diabetic subjects. ... Cited by 28 - Related articles - BL Direct - All 5 versions
C Baker, LG Petrich de Marquesini, AJ … - Journal of Clinical Immunology, 2008 - Springer Abstract Purpose In this study, we explored the breadth of CD8 T cell reactivity
to preproinsulin (PPI) in type 1 diabetes. Materials and Methods We tested a
complete peptide set in pools covering all 406 potential 8–11mer epitopes ... Cited by 6 - Related articles - All 2 versions
Y Hassainya, F Garcia-Pons, R Kratzer, V … - Diabetes, 2005 - Am Diabetes Assoc Type 1 diabetes is thought to result from the destruction of β-cells by
autoantigen-specific T-cells. Observations in the NOD mouse model suggest that
CD8 + cytotoxic T-cells play an essential role in both the initial ... Cited by 43 - Related articles - All 6 versions
