AR Burton, E Vincent, PY Arnold, GP Lennon, M … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Neither GAD- nor IA2-specific TCRs mediated T-cell islet infiltration or diabetes even
though T-cells developed in these Rg mice and responded to their cognate epitope. IA2β/phogrin
and insulin-specific Rg T-cells produced variable levels of insulitis, with one TCR ... Cited by 8 - Related articles - BL Direct - All 4 versions
M von Herrath, GT Nepom - Nature Immunology, 2009 - nature.com Type 1 diabetes is an immune-mediated disease in which pancreatic insulin-producing beta
cells are damaged and destroyed. Animal models have served a prominent function in the development
of the present ideas of pathogenesis and approaches to therapy. This commentary ... Cited by 4 - Related articles - All 3 versions
DV SERREZE, MP MARRON, TP … - Annals of the New York …, 2007 - interscience.wiley.com Abstract : The mechanistic basis by which the H2 g7 major histocompatibility complex (MHC)
provides the primary risk factor for the development of T cell–mediated autoimmune type 1 diabetes
(T1D) in non-obese diabetic (NOD) mice involves contributions not only from the unusual ... Cited by 3 - Related articles - BL Direct - All 5 versions
- ►pnas.org M Kobayashi, J Jasinski, E Liu, M Li, D … - Proceedings of the …, 2008 - National Acad Sciences A fundamental question is what are the molecular determinants that lead to spontaneous preferential
targeting of specific autoantigens in autoimmune diseases, such as the insulin B:9–23 peptide
sequence in type 1 diabetes. Anti-insulin B:9–23 T cell clones isolated from prediabetic ... Cited by 3 - Related articles - All 5 versions
H Moriyama, M Nagata, T Arai, Y Okumachi, K … - Diabetes Research and …, 2007 - Elsevier Rodents have two functional preproinsulin genes named insulin 1 and insulin 2 on different chromosome
and have two amino acid differences in insulin B chain. We have established insulin 1 or insulin
2 knockout (KO) non-obese diabetic (NOD) colonies in the animal institute of Kobe ... Cited by 4 - Related articles - All 9 versions
- ►unair.ac.id [PDF] MW Appleby, F Ramsdell - Curr Top Microbiol Immunol, 2008 - Springer Abstract The ability to rapidly and efficiently recognize and eliminate pathogens while sparing
normal self tissue is a hallmark of the mammalian immune system. When it fails, however, autoimmune
disease results. The genetic and environmental factors that control the process of making ... Cited by 4 - Related articles - All 4 versions
M von Herrath, GT Nepom, B … - European Journal of …, 2009 - interscience.wiley.com Type 1 diabetes (T1D) occurs when the immune system attacks the insulin-producing beta cells
located in the islets of Langerhans within the pancreas. Animal models have played a prominent
role in developing an understanding of this disease process, through studies of genetic ... Related articles - All 2 versions
L Zhang, JM Jasinski, M Kobayashi, B Davenport, K … - Journal of Autoimmunity, 2009 - Elsevier Hybridomas with the complete BDC12-4.1 and BDC12-4.4 T cell receptors, despite having markedly
different TCR beta chains, responded to similar B:9-23 peptides. Approximately 1% of the hybridomas
from mice with the fixed TRAV5D-4*04 alpha chains and multiple endogenous beta ... Related articles - All 2 versions
- ►rupress.org C Louvet, BG Kabre, DW Davini, N Martinier, … - Journal of Experimental …, 2009 - jem.rupress.org Autoimmune-prone nonobese diabetic mice deficient for B7-2 spontaneously develop an autoimmune
peripheral neuropathy mediated by inflammatory CD4 + T cells that is reminiscent of
Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy. To ... Related articles - All 4 versions
BA Wicklow, C Polychronakos - Expert Review of Clinical …, 2009 - ingentaconnect.com Mounting evidence suggests insulin is an important and potentially initiating antigen in the pathogenesis
of Type 1 diabetes. High-affinity insulin antibodies are found early in disease development and
appear to predict progression. Insulin is the only Type 1 diabetes auto-antigen with ... Related articles - All 3 versions
