- ►diabetesjournals.org L Valenti, R Rametta, P Dongiovanni, M Maggioni, A … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Nonalcoholic fatty liver, affecting 34% of the US population, is characterized by
hepatic insulin resistance, which is more marked in the presence of steatohepatitis, and frequently
precedes hyperglycemia. The molecular mechanisms underlying the relationship ... Cited by 14 - Related articles - BL Direct - All 3 versions
A Kamagate, S Qu, G Perdomo, D Su, DH … - The Journal of …, 2008 - pubmedcentral.nih.gov Excessive production of triglyceride-rich VLDL is attributable to hypertriglyceridemia. VLDL production
is facilitated by microsomal triglyceride transfer protein (MTP) in a rate-limiting step that is regulated
by insulin. To characterize the underlying mechanism, we studied hepatic MTP regulation ... Cited by 16 - Related articles - BL Direct - All 7 versions
- ►physiology.org MAM den Boer, PJ Voshol, F Kuipers, JA … - American Journal of …, 2006 - Am Physiological Soc Insulin is an important inhibitor of both hepatic glucose output and hepatic VLDL-triglyceride
(VLDL-TG) production. We investigated whether both processes are equally sensitive to
insulin-mediated inhibition. To test this, we used euglycemic clamp studies with four ... Cited by 4 - Related articles - BL Direct - All 3 versions
- ►endojournals.org S Qu, J Altomonte, G Perdomo, J He, Y Fan, A … - Endocrinology, 2006 - Endocrine Soc FoxO1 plays an important role in mediating the effect of insulin on hepatic metabolism. Increased
FoxO1 activity is associated with reduced ability of insulin to regulate hepatic glucose
production. However, the underlying mechanism and physiology remain unknown. We ... Cited by 14 - Related articles - BL Direct - All 5 versions
LL Swift, A Jovanovska, B Kakkad, DE Ong - Histochemistry and cell biology, 2005 - Springer Abstract Immunohistochemical and biochemical ap- proaches were utilized to compare the expression
of microsomal triglyceride transfer protein (MTP) and cellular retinol binding protein II
(CRBPII) with the expression of apolipoprotein (apo)B and apoA-I along the entire length ... Cited by 7 - Related articles - All 3 versions
K Sekine, YR Chen, N Kojima, K Ogata, A … - The EMBO …, 2007 - pubmedcentral.nih.gov C/EBPα is a key transcription factor indispensable for the onset of gluconeogenesis in perinatal
liver. However, C/EBPα was already expressed in fetal liver, suggesting that the expression of
C/EBPα alone does not account for the dramatic increase of the expression of metabolic ... Cited by 9 - Related articles - BL Direct - All 7 versions
- ►cell.com M Matsumoto, A Pocai, L Rossetti, RA DePinho, D … - Cell metabolism, 2007 - Elsevier The hallmark of type 2 diabetes is excessive hepatic glucose production. Several transcription
factors and coactivators regulate this process in cultured cells. But gene ablation experiments
have yielded few clues as to the physiologic mediators of this process in vivo. We show ... Cited by 43 - Related articles - All 9 versions
- ►diabetesjournals.org VT Samuel, CS Choi, TG Phillips, AJ Romanelli, JG … - Diabetes, 2006 - Am Diabetes Assoc Fasting hyperglycemia, a prominent finding in diabetes, is primarily due to increased
gluconeogenesis. The transcription factor Foxo1 links insulin signaling to decreased transcription
of PEPCK and glucose-6-phosphatase (G6Pase) and provides a possible therapeutic ... Cited by 47 - Related articles - BL Direct - All 6 versions
- ►physiology.org S Qu, D Su, J Altomonte, A Kamagate, J … - American Journal of …, 2007 - Am Physiological Soc High-fructose consumption is associated with insulin resistance and diabetic dyslipidemia, but
the underlying mechanism is unclear. We show in hamsters that high-fructose feeding stimulated
forkhead box O1 (FoxO1) production and promoted its nuclear redistribution in liver, ... Cited by 26 - Related articles - BL Direct - All 6 versions
- ►cell.com XC Dong, KD Copps, S Guo, Y Li, R Kollipara, RA … - Cell metabolism, 2008 - Elsevier The forkhead transcription factor Foxo1 regulates expression of genes involved in stress resistance
and metabolism. To assess the contribution of Foxo1 to metabolic dysregulation during hepatic
insulin resistance, we disrupted Foxo1 expression in the liver of mice lacking hepatic Irs1 ... Cited by 12 - Related articles - All 11 versions
