M Saberi, MA Bohland, CM Donovan - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Inducing hypoglycemia slowly, at a rate of −0.09 mmol · l −1 · min −1 , resulted in
a 26-fold increase in epinephrine (23.39 ± 0.62 nmol/l) and 12-fold increase in norepinephrine
(11.42 ± 0.92 nmol/l) for controls (P < 0.001). The epinephrine response to hypoglycemia ... Cited by 7 - Related articles - BL Direct - All 4 versions
- ►physiology.org AC Ertl, S Mann, A Richardson, VJ Briscoe … - American Journal of …, 2008 - Am Physiological Soc The effects of oral carbohydrate on modulating counterregulatory responses in humans remain
undecided. This study's specific aim was to determine the effects of oral carbohydrate on autonomic
nervous system (ANS) and neuroendocrine responses during hyperinsulinemic ... Cited by 3 - Related articles - All 4 versions
AD Cherrington - Diabetes, 2008 - Am Diabetes Assoc One of the most significant limits in our ability to tightly control blood glucose in patients with
diabetes is the occurrence of hypoglycemia. It is now clear that when blood glucose drops in
a normal individual, there is a rapid and well-coordinated endocrine response (1). ... Cited by 1 - Related articles - BL Direct - All 3 versions
P Rossetti, F Porcellati, P Lucidi, N Busciantella Ricci, … - Diabetes, 2009 - Am Diabetes Assoc OBJECTIVE—Experimental data from animal studies indicate that portal vein glucose sensors
play a key role in the responses to slow-fall hypoglycemia. However, their role in modulating
these responses in humans is not well understood. The aim of the present study was to ... Cited by 1 - Related articles - All 3 versions
- ►physiology.org AV Matveyenko, MA Bohland, M Saberi, … - American Journal of …, 2007 - Am Physiological Soc Antecedent hypoglycemia leads to impaired counterregulation and hypoglycemic
unawareness. To ascertain whether antecedent portal vein hypoglycemia impairs portal vein
glucose sensing, thereby inducing counterregulatory failure, we compared the effects of ... Cited by 2 - Related articles - BL Direct - All 3 versions
- ►physiology.org S Fujita, MA Bohland, G Sanchez-Watts, … - American Journal of …, 2007 - Am Physiological Soc To elucidate the type of spinal afferent involved in hypoglycemic detection at the portal vein,
we considered the potential role of capsaicin-sensitive primary sensory neurons.
Specifically, we examined the effect of capsaicin-induced ablation of portal vein afferents ... Cited by 7 - Related articles - BL Direct - All 6 versions
- ►endojournals.org RA Heptulla, WV Tamborlane, TYZ Ma, F … - Journal of Clinical …, 2001 - Endocrine Soc It has been suggested that the counterregulatory hormone (CRH) response to acute hypoglycemia
is triggered via glucose sensors situated in either the hypothalamus or the portohepatic
area. If the latter were critical during hypoglycemia, one would anticipate that ingestion of ... Cited by 13 - Related articles - BL Direct - All 5 versions
D Smith, A Pernet, H Reid, E Bingham, J Rosenthal, I … - Diabetologia, 2002 - Springer Aims/hypothesis. The role of glucose sensing cells in the human hepatic portal system in the
initiation of the neuroendocrine responses to acute hypoglycaemia is not known. We investigated
the effect of raising blood glucose concentrations in the hepatic-portal vein on ... Cited by 18 - Related articles - BL Direct - All 3 versions
S Fujita, CM Donovan - Diabetes, 2005 - Am Diabetes Assoc Afferent innervation of the portal vein has been shown to be critical in hypoglycemic
detection, but the neural pathway by which these afferents ascend remains unknown. To ascertain
the role of vagal afferents versus spinal afferents in hypoglycemic detection, the ... Cited by 14 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org X Fan, Y Ding, H Cheng, DX Gram, RS Sherwin, RJ … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— In glucose-sensing neurons, ATP-sensitive K + channels (K ATP channels) are
thought to translate metabolic signals into an alteration in neuronal firing rates. Because these
neurons express the Kir6.2/SUR-1 isoform of the K ATP channel, we sought to examine ... Related articles - All 4 versions
