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Scholar Results 1 - 10 of about 101 related to Gubitosi-Klug: 5-Lipoxygenase, but not 12/15-Lipoxygenase, contributes to degeneration of.... (0.11 sec) 

5-Lipoxygenase, but not 12/15-Lipoxygenase, contributes to degeneration of …

- diabetesjournals.org
RA Gubitosi-Klug, R Talahalli, Y Du, JL Nadler, TS … - Diabetes, 2008 - Am Diabetes Assoc
RESULTS—Diabetic wild-type mice developed the expected degeneration of retinal capillaries
and pericytes and increases in both leukostasis and superoxide production (P < 0.006). We found
no evidence of diabetes-induced degeneration of retinal ganglion cells in these animals. ...
Cited by 3 - Related articles - BL Direct - All 4 versions

Biosynthesis of eicosanoids and transcellular metabolism of leukotrienes in murine …

- jlr.org
MA Gijon, S Zarini, RC Murphy - The Journal of Lipid Research, 2007 - ASBMB
Leukotriene B 4 (LTB 4 ) biosynthesis by polymorphonuclear leukocytes (PMNs) is an important
factor of inflammatory responses. PMNs also release LTA 4 , an unstable intermediate that can
be taken up by neighboring cells and metabolized into LTC 4 . Most studies of LT ...
Cited by 3 - Related articles - All 4 versions

Endothelial proliferation in diabetic retinal microaneurysms


E Aguilar, M Friedlander, RF Gariano - Archives of ophthalmology, 2003 - archopht.highwire.org
Eyes were obtained within 12 hours of death from 5 patients with diabetes mellitus. The eyes
were fixed in 4% paraformaldehyde, the corneas were removed, and the retinas were examined
using a dissection microscope for pathological evidence of diabetic retinopathy. Retinas ...
Cited by 7 - Related articles - BL Direct - All 4 versions

Licofelone: The answer to unmet needs in osteoarthritis therapy?


SK Kulkarni, VP Singh - Current rheumatology reports, 2008 - Springer
Licofelone, a competitive inhibitor of cyclooxygenases 1 and 2 and 5-lipoxygenase enzyme,
is under clini- cal evaluation for its effectiveness in the treatment of osteoarthritis (OA). Licofelone
decreases the produc- tion of both prostaglandins and leukotrienes and has been shown ...
Cited by 2 - Related articles - BL Direct - All 2 versions

Cardiovascular effects of valdecoxib: transducing human pharmacology results into …


ML Capone, S Tacconelli, LD Francesco, M … - Expert Opin. Drug …, 2008 - informahealthcare.com
Valdecoxib is an NSAID that is selective for COX-2 (commonly named coxibs). It exhibits
anti-inflammatory, analgesic and antipyretic properties in animal models and humans due to
inhibition of prostanoid synthesis primarily by affecting COX-2. In this review, the clinical ...
Cited by 2 - Related articles - BL Direct - All 5 versions

[CITATION] Regulating inflammation: The ying and yang of NF-κB activation


ST Grey - Immunology and Cell Biology, 2008 - nature.com
Jump to main content; Jump to navigation; nature.com homepage; Publications AZ index;
Browse by subject; ASI. My account; Submit manuscript; Register; Subscribe. Advertisement.
Login. Immunology and Cell Biology homepage Search This journal. ...
Cited by 2 - Related articles - All 3 versions

The mast cell and the cysteinyl leukotrienes.


KF Austen - Novartis Foundation symposium, 2005 - ncbi.nlm.nih.gov
The mast cell has been a fundamental focus for nearly half a century in the effort to understand
the biology of the cysteinyl leukotrienes (cysLTs). My initial interest in the cysLTs, once termed
the slow reacting substance of anaphylaxis (SRS-A), was based on the findings of others ...
Cited by 8 - Related articles - BL Direct - All 3 versions

Synthesis, molecular modelling and enzymatic evaluation of (±) 3, 5-diphenyl-2- …


MP Gauthier, C Michaux, S Rolin, C Vastersaegher, … - Bioorganic & medicinal …, 2006 - Elsevier
A series of substituted (±)3,5-diphenyl-2-thioxoimidazolin-4-ones was synthesized in order to
design new type-2 cyclooxygenase (COX-2) inhibitors. This study has led to molecules which
completely inhibit human recombinant COX-2 at 50 μM. Molecular modelling highlighted ...
Cited by 3 - Related articles - All 4 versions

Janus kinase 3 inhibitor WHI-P154 in macrophages activated by bacterial …


O Sareila, R Korhonen, O Kärpänniemi, R … - International …, 2007 - Elsevier
Bacterial endotoxin is a potent inducer of inflammatory response, including the induction of inducible
nitric oxide synthase (iNOS) expression and nitric oxide (NO) production, and the expression
of cyclo-oxygenase (COX)-2 and tumor necrosis factor (TNF)-α in inflammatory cells. In ...
Cited by 3 - Related articles - All 3 versions

New celecoxib derivatives as anti-inflammatory agents


G Szabó, J Fischer, Á Kis-Varga, K Gyires - Journal of medicinal chemistry, 2007 - pubs.acs.org
A series of 1,5-diarylpyrazoles with a substituted benzenesulfonamide moiety was synthesized
and evaluated for cyclooxygenase (COX-1/COX-2) inhibitory activities. Some compounds, for
example, (±)-2-[4-(5-p-tolyl-3-trifluoromethyl-pyrazole-1-yl)-benzenesulfonylaminooxy]- ...
Cited by 3 - Related articles - All 3 versions


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