- ►diabetesjournals.org K Bouzakri, R Austin, A Rune, ME Lassman, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—RNA interference–based silencing of MCD expression (75% reduction)
increased malonyl-CoA levels twofold and shifted substrate utilization from
lipid to glucose oxidation. RNA interference–based depletion of MCD ... Cited by 15 - Related articles - All 5 versions
NL Dzamko, JD Schertzer, J Ryall, R Steel, … - The Journal of Physiology, 2008 - Physiological Soc The activation of AMP-activated protein kinase (AMPK) and
phosphorylation/inhibition of acetyl-CoA carboxylase 2 (ACC2) is believed to be
the principal pathway regulating fatty acid oxidation. However, during ... Cited by 13 - Related articles - All 5 versions
AC Smith, CR Bruce, DJ Dyck - J. Physiol, 2005 - Physiological Soc Page 1. 1 AICAR further increases fatty acid oxidation and blunts
triacylglycerol hydrolysis in contracting rat soleus muscle Angela ... Cited by 3 - Related articles
PM Garcia-Roves, ME Osler, MH Holmström, … - Journal of Biological Chemistry, 2008 - ASBMB AMP-activated protein kinase (AMPK) is a heterotrimeric complex, composed of a
catalytic subunit (α) and two regulatory subunits (β and γ), that works as a
cellular energy sensor. The existence of multiple heterotrimeric complexes ... Cited by 5 - Related articles - All 3 versions
- ►physiology.org MF Essop, HS Camp, CS Choi, S Sharma, RM … - American Journal of Physiology- Heart and Circulatory …, 2008 - Am Physiological Soc The cardiac-enriched isoform of acetyl-CoA carboxylase (ACC2) is a key regulator
of mitochondrial fatty acid (FA) uptake via carnitine palmitoyltransferase 1
(CPT1). To test the hypothesis that oxidative metabolism is upregulated in ... Cited by 5 - Related articles - All 5 versions
- ►diabetesjournals.org CR Bruce, AJ Hoy, N Turner, MJ Watt, TL … - Diabetes, 2009 - Am Diabetes Assoc OBJECTIVE—Skeletal muscle insulin resistance is associated with lipid
accumulation, but whether insulin resistance is due to reduced or enhanced flux
of long-chain fatty acids into the mitochondria is both controversial and ... Cited by 7 - Related articles - All 3 versions
- ►cell.com TR Koves, JR Ussher, RC Noland, D Slentz, … - Cell metabolism, 2008 - Elsevier Previous studies have suggested that insulin resistance develops secondary to
diminished fat oxidation and resultant accumulation of cytosolic lipid molecules
that impair insulin signaling. Contrary to this model, the present study ... Cited by 120 - Related articles - All 9 versions
JT Treebak, C Frøsig, C Pehmøller, S Chen, … - Diabetologia, 2009 - Springer Page 1. ARTICLE Potential role of TBC1D4 in enhanced post-exercise insulin
action in human skeletal muscle JT Treebak & C. Frøsig ... Cited by 7 - Related articles - All 2 versions
EA Richter, NB Ruderman - The Biochemical journal, 2009 - ncbi.nlm.nih.gov AMPK (AMP-activated protein kinase) is a phylogenetically conserved fuel-sensing
enzyme that is present in all mammalian cells. During exercise, it is activated
in skeletal muscle in humans, and at least in rodents, also in adipose ... Cited by 12 - Related articles - All 3 versions
- ►physiology.org NH Jeoung, RA Harris - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc The effect of pyruvate dehydrogenase kinase-4 (PDK4) deficiency on glucose
homeostasis was studied in mice fed a high-fat diet. Expression of PDK4 was
greatly increased in skeletal muscle and diaphragm but not liver and kidney ... Cited by 12 - Related articles - All 6 versions
