JW Tomlinson, J Finney, BA Hughes, SV Hughes, PM … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Before weight loss, fat mass correlated with glucocorticoid secretion rate (total
fat, r = 0.46, P < 0.05; trunk fat, r = 0.52, P < 0.05); however, glucocorticoid secretion rate was
inversely related to insulin sensitivity (r = −0.51, P < 0.05). Hyperinsulinemia failed to ... Cited by 10 - Related articles - All 4 versions
- ►diabetesjournals.org [PDF] JW Tomlinson, J Finney, C Gay, BA Hughes, SV … - Diabetes, 2008 - Am Diabetes Assoc Page 1. Glucocorticoid metabolism and insulin sensitivity 1 Impaired glucose tolerance and
insulin resistance are associated with increased adipose 11β-hydroxysteroid dehydrogenase
type 1 expression and elevated hepatic 5α-reductase activity ... Cited by 6 - Related articles - All 5 versions
DE Livingstone, KJ McInnes, BR Walker, R Andrew - Obesity research, 2005 - ncbi.nlm.nih.gov OBJECTIVE: Obesity is associated with altered glucocorticoid metabolism, which may impact
on hypothalamic-pituitary-adrenal axis activity. Here we characterize hepatic 5alpha- and
5beta-reductase in obese rats and their responses to insulin sensitization. RESEARCH ... Cited by 8 - Related articles - BL Direct - All 2 versions
- ►jbc.org EA Walker, A Ahmed, GG Lavery, JW Tomlinson, … - Journal of Biological …, 2007 - ASBMB Microsomal glucose-6-phosphatase- (G6Pase- ) and glucose 6-phosphate transporter
(G6PT) work together to increase blood glucose concentrations by performing the terminal step
in both glycogenolysis and gluconeogenesis. Deficiency of the G6PT in liver gives rise to ... Cited by 14 - Related articles - All 5 versions
- ►aspetjournals.org [PDF] BG Bhat, N Hosea, A Fanjul, J Herrera, J Chapman, … - Journal of Pharmacology …, 2007 - ASPET Page 1. JPET #128280 1 Title Demonstration of Proof of Mechanism and
Pharmacokinetics and Pharmacodynamic Relationship with PF-915275, an Inhibitor
of 11βHSD1, in Cynomolgus Monkeys. B. Ganesh Bhat, Natilie Hosea ... Cited by 4 - Related articles
I Melin, C Falconer, S Rössner, D Altman - Obesity Research & Clinical Practice, 2007 - Elsevier The questionnaire was completed and returned by 279/446 of the patients (62%) and 430/892
control subjects (48%). Compared to the non-obese control group, obese women reported a
significantly increased prevalence and bother of nocturia (p < 0.001), frequent urination (p ... Cited by 6 - Related articles
- ►endojournals.org [PDF] JW Tomlinson, M Sherlock, B Hughes, SV … - Journal of Clinical …, 2007 - Endocrine Soc Page 1. 1 Inhibition of 11β-HSD1 activity in vivo limits glucocorticoid exposure to human adipose
tissue and decreases lipolysis. Short title: 11β-HSD1 inhibition and lipolysis Jeremy W Tomlinson
1 , Mark Sherlock 1 , Beverley Hughes 1 , Susan V Hughes 1 , Fiona ... Cited by 8 - Related articles
- ►endojournals.org RH Stimson, AM Johnstone, NZM Homer, DJ … - Journal of Clinical …, 2007 - Endocrine Soc Context: Dietary macronutrient composition influences cardiometabolic health independently
of obesity. Both dietary fat and insulin alter glucocorticoid metabolism in rodents and,
acutely, in humans. However, whether longer-term differences in dietary macronutrients ... Cited by 9 - Related articles - BL Direct - All 5 versions
R Stephan, M Claude - jobb.lakartidningen.se banner. Författare: Rössner Stephan, Marcus Claude Titel: Fetmans
skadepanorama mer omfattande än tidigare känt. Obesitas ger multipla
komplikationer - flertalet specialister berörs (mk) 2008 nr 34 sid 2239-40 ... Related articles - Cached - All 2 versions
- ►nih.gov DEW Livingstone, SL Grassick, GL Currie, … - Journal of …, 2009 - Soc Endocrinology In obese humans, metabolism of glucocorticoids by 11β-hydroxysteroid dehydrogenase type
1 (11β-HSD1) and A-ring reduction (by 5 - and 5β-reductases) is dysregulated in a tissue specific
manner. These changes have been recapitulated in leptin resistant obese Zucker rats but ... Related articles - All 6 versions
