- ►diabetesjournals.org HA Russ, Y Bar, P Ravassard, S Efrat - Diabetes, 2008 - Am Diabetes Assoc RESULTS— β-Cells were efficiently and specifically labeled by the dual virus system. Label
+ , insulin − cells derived from β-cells were shown to proliferate for a maximum of 16 population
doublings, with an approximate doubling time of 7 days. Isolated labeled cells could be ... Cited by 20 - Related articles - All 4 versions
- ►diabetesjournals.org F Atouf, CH Park, K Pechhold, M Ta, Y Choi, NL … - Diabetes, 2007 - Am Diabetes Assoc We used cre/loxP-based genetic lineage tracing analysis to test a previously proposed hypothesis
that in vitro cultured adult pancreatic β-cells undergo epithelial-mesenchymal transition
(EMT) to generate a highly proliferative, differentiation-competent population of ... Cited by 31 - Related articles - BL Direct - All 5 versions
N Weinberg, L Ouziel-Yahalom, S Knoller, S Efrat, Y … - Diabetes, 2007 - Am Diabetes Assoc Understanding and manipulating pancreatic β-cell proliferation is a major challenge for pancreas
biology and diabetes therapy. Recent studies have raised the possibility that human β-cells can
undergo dedifferentiation and give rise to highly proliferative mesenchymal cells, which ... Cited by 37 - Related articles - BL Direct - All 5 versions
- ►alphamedpress.org B Davani, L Ikonomou, BM Raaka, E Geras-Raaka, RA … - Stem Cells, 2007 - AlphaMed Press Islet transplantation offers improved glucose homeostasis in diabetic patients, but transplantation
of islets is limited by the supply of donor pancreases. Undifferentiated precursors hold promise
for cell therapy because they can expand before differentiation to produce a large supply ... Cited by 29 - Related articles - BL Direct - All 5 versions
R Gallo, F Gambelli, B Gava, F Sasdelli, V Tellone … - Cell Death & …, 2007 - nature.com Cellular models and culture conditions for in vitro expansion of insulin-producing cells represent
a key element to develop cell therapy for diabetes. Initial evidence that human -cells could be
expanded after undergoing a reversible epithelial–mesenchymal transition has been ... Cited by 14 - Related articles - BL Direct - All 5 versions
- ►nih.gov RA Morton, E Geras-Raaka, LM Wilson, BM Raaka, … - Molecular and cellular …, 2007 - Elsevier We previously presented evidence that proliferative human islet precursor cells may be derived
in vitro from adult islets by epithelial-to-mesenchymal transition (EMT) and show here that similar
fibroblast-like cells can be derived from mouse islets. These mouse cell populations ... Cited by 29 - Related articles - All 5 versions
Y Bar, HA Russ, S Knoller, L Ouziel-Yahalom, S Efrat - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—In vitro expansion of β-cells from adult human islets could solve the tissue shortage
for cell replacement therapy of diabetes. Culture of human islet cells typically results in <16 cell
doublings and loss of insulin expression. Using cell lineage tracing, we demonstrated that ... Cited by 3 - Related articles - All 4 versions
LG Chase, F Ulloa-Montoya, BL Kidder, CM Verfaillie - Diabetes, 2007 - Am Diabetes Assoc As recent studies suggest that newly formed pancreatic β-cells are a result of self-duplication
rather than stem cell differentiation, in vitro expansion of β-cells presents a potential mechanism
by which to increase available donor tissue for cell-based diabetes therapies. Although ... Cited by 42 - Related articles - BL Direct - All 7 versions
JJ Meier, AE Butler, Y Saisho, T Monchamp, R Galasso … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE— Little is known about the capacity, mechanisms, or timing of growth in β-cell mass
in humans. We sought to establish if the predominant expansion of β-cell mass in humans occurs
in early childhood and if, as in rodents, this coincides with relatively abundant β-cell ... Cited by 23 - Related articles - All 3 versions
L Ouziel-Yahalom, M Zalzman, L Anker-Kitai, S … - … and Biophysical Research …, 2006 - Elsevier Type 1 diabetes is caused by autoimmune destruction of the pancreatic islet insulin-producing
β cells. Insulin administration does not prevent long-term complications of the disease, since
the optimal insulin dosage is difficult to adjust. Replacement of the damaged cells with ... Cited by 54 - Related articles - All 4 versions
