M Braun, R Ramracheya, M Bengtsson, Q … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— Human β-cells express two types of voltage-gated K + currents that
flow through delayed rectifying (K V 2.1/2.2) and large-conductance Ca 2+
-activated K + (BK) channels. Blockade of BK channels (using iberiotoxin) ... Cited by 14 - Related articles - All 5 versions
- ►nih.gov J Herrington, M Sanchez, D Wunderler, L Yan … - The Journal of Physiology, 2005 - Physiological Soc Voltage-gated potassium (Kv) currents of human pancreatic islet cells were
studied by whole-cell patch clamp recording. On average, 75% of the cells tested
were identified as β-cells by single cell, post-recording RT-PCR for ... Cited by 10 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org JC Henquin, D Dufrane, M Nenquin - Diabetes, 2006 - Am Diabetes Assoc Pancreatic islets were isolated from 16 nondiabetic organ donors and, after
culture for ∼2 days in 5 mmol/l glucose, were perifused to characterize
nutrient-induced insulin secretion in human islets. Stepwise increases from ... Cited by 16 - Related articles - BL Direct - All 5 versions
Q Zhang, M Bengtsson, C Partridge, A Salehi, … - Nature cell biology, 2007 - nature.com Pancreatic islets have a central role in blood glucose homeostasis. In addition
to insulin-producing -cells and glucagon-secreting -cells, the islets contain
somatostatin-releasing -cells 1 . Somatostatin is a powerful inhibitor of ... Cited by 6 - Related articles - BL Direct - All 4 versions
- ►nih.gov ME Meyer-Hermann - Biophysical Journal, 2007 - Elsevier The electrophysiology of β-cells is at the origin of insulin secretion.
β-Cells exhibit a complex behavior upon stimulation with glucose including
repeated bursts and continuous spiking. Mathematical modeling is most ... Cited by 5 - Related articles - BL Direct - All 11 versions
DA Jacobson, LH Philipson - Diabetes Obesity and Metabolism, 2007 - interscience.wiley.com Coordinated electrical activity allows pancreatic β-cells to respond to
secretagogues with calcium entry followed by insulin secretion. Metabolism of
glucose affects multiple membrane proteins including ion channels, ... Cited by 5 - Related articles - All 2 versions
- ►nih.gov S Vignali, V Leiss, R Karl, F Hofmann, A … - The Journal of Physiology, 2006 - Physiological Soc Insulin and glucagon are the major hormones of the islets of Langerhans that are
stored and released from the B- and A-cells, respectively. Both hormones are
secreted when the intracellular cytosolic Ca 2+ concentration ([Ca 2+ ] i ) ... Cited by 18 - Related articles - BL Direct - All 7 versions
- ►physiology.org R Cruz-Cruz, A Salgado, C Sanchez-Soto, L … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc Glucose-induced insulin secretion by pancreatic -cells depends on membrane
depolarization and [Ca 2+ ] i increase. We correlated voltage- and current-clamp
recordings, [Ca 2+ ] i measurements, and insulin reverse hemolytic plaque ... Cited by 7 - Related articles - BL Direct - All 4 versions
- ►nih.gov DA Jacobson, A Kuznetsov, JP Lopez, S Kash, … - Cell metabolism, 2007 - Elsevier Voltage-gated potassium currents (Kv), primarily due to Kv2.1 channels, are
activated by glucose-stimulated pancreatic β cell depolarization, but the exact
role (or roles) of this channel in regulating insulin secretion remains ... Cited by 7 - Related articles - All 5 versions
- ►shouxi.net SJ Bailey, MA Ravier, GA Rutter - Diabetes, 2007 - Am Diabetes Assoc The mechanism(s) by which glucose regulates glucagon secretion both acutely and
in the longer term remain unclear. Added to isolated mouse islets in the
presence of 0.5 mmol/l glucose, γ-aminobutyric acid (GABA) inhibited ... Cited by 9 - Related articles - BL Direct - All 7 versions
