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Scholar Results 1 - 10 of about 101 related to Peng: RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease. (0.11 sec) 

RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease


F Peng, D Wu, B Gao, AJ Ingram, B Zhang, K … - Diabetes, 2008 - Am Diabetes Assoc
RESULTS—Glucose led to RhoA and downstream Rho-kinase activation. Mannitol was
without effect. Activity of the transcription factor AP-1, increased in diabetic
MCs and kidneys, is important in the profibrotic effects of glucose, and ...
Cited by 10 - Related articles - All 4 versions

Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy …

- diabetesjournals.org
V Kolavennu, L Zeng, H Peng, Y Wang, FR … - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—RhoA, a small GTPase protein, and its immediate downstream target,
Rho kinase (ROCK), control a wide variety of signal transduction pathways.
Recent studies have shown that fasudil, a selective ROCK inhibitor, may ...
Cited by 16 - Related articles - BL Direct - All 4 versions

Effects on protein kinase C-beta inhibition on glomerular vascular endothelial growth …

- physiology.org [PDF] 
DJ Kelly, D Buck, AJ Cox, Y Zhang, RE Gilbert - American Journal of Physiology- Renal Physiology, 2007 - Am Physiological Soc
31 articles, 22 of which you can access free at: This article cites
http://ajprenal.physiology.org/cgi/content/full/293/2/F565#BIBL ... 4 other
HighWire hosted articles: This article has been cited by
Cited by 11 - Related articles - BL Direct - All 5 versions

Recent advances in pharmacotherapy for diabetic nephropathy: current perspectives and …


P Balakumar, MK Arora, SS Ganti, J Reddy, M … - Pharmacological Research, 2009 - Elsevier
Chronic diabetes mellitus is associated with various complications such as
retinopathy, neuropathy, nephropathy, cardiomyopathy, vasculopathy, dermatopathy
and encephalopathy. Nephropathy is one of the major complications of ...
Cited by 1 - Related articles - All 2 versions

Suppressor of cytokine signaling-1 reduces high glucose-induced TGF-β1 and fibronectin …


Y Shi, Y Zhang, C Wang, C Du, S Zhao, Z Qi, … - FEBS letters, 2008 - Elsevier
Janus kinase (JAK) signal transducers, and activators of transcription (STAT),
contribute to diabetic nephropathy. Here we show that one of the suppressors of
cytokine signaling (SOCS) proteins, SOCS-1, was upregulated in human ...
Cited by 1 - Related articles - All 15 versions

The effects of spironolactone on nephron function in patients with diabetic nephropathy


A Ustundag, A Tugrul, S Ustundag, N Sut, B … - Renal Failure, 2008 - informahealthcare.com
Increasing evidence suggests that circulating aldosterone per se contributes
directly to renal and cardiovascular diseases. We sought to evaluate the effects
of a three-month treatment with 25 mg spironolactone, an aldosterone ...
Cited by 2 - Related articles - All 5 versions

Emerging role of PPAR ligands in the management of diabetic nephropathy


P Balakumar, MK Arora, M Singh - Pharmacological Research, 2009 - Elsevier
Diabetes mellitus, a chronic metabolic disorder, is associated with an increased
risk of microvascular and macrovascular complications that include nephropathy,
retinopathy, neuropathy, coronary artery disease, peripheral arterial ...
Cited by 2 - Related articles - All 2 versions

Green tea (Camellia sinensis) attenuates nephropathy by downregulating Nox4 NADPH …


PDB Ribaldo, DS Souza, SK Biswas, K Block, … - Journal of Nutrition, 2009 - Am Soc Nutrition
Green tea (GT), through its antioxidant properties, may be useful to treat or
prevent human diseases. Because several lines of evidence suggest that oxidative
stress contributes to the pathogenesis of diabetic nephropathy, we tested ...
Cited by 3 - Related articles - All 3 versions

Effects of NADPH oxidase inhibitor on diabetic nephropathy in OLETF rats: The role of reducing …


SM Nam, MY Lee, JH Koh, JH Park, JY Shin, … - Diabetes Research and Clinical Practice, 2009 - Elsevier
Sixteen Otsuka Long Evans Tokushima Fatty (OLETF) rats and 9 Long Evans
Tokushima Otsuka (LETO) were divided into the following three groups: LETO rats
(n = 9), control OLETF rats (n = 7) and apocynin-treated OLETF rats (n = ...
Cited by 2 - Related articles - All 19 versions

Vascular endothelial dysfunction: A tug of war in diabetic nephropathy?


P Balakumar, VA Chakkarwar, P Krishan, M … - Biomedicine & Pharmacotherapy, 2009 - Elsevier
Vascular endothelium regulates vascular tone and maintains free flow of blood in
vessels. Vascular endothelial dysfunction (VED) results in reduced activation of
endothelial nitric oxide synthase (eNOS), reduced generation and ...
Cited by 9 - Related articles - All 2 versions


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