CC Féral, JG Neels, C Kummer, M Slepak, JM Olefsky, … - Diabetes, 2008 - Am Diabetes Assoc OBJECTIVE—Many prevalent diseases of advanced societies, such as obesity-induced type
2 diabetes, are linked to indolent mononuclear cell–dependent inflammation. We previously
proposed that blockade of α4 integrin signaling can inhibit inflammation while limiting ... Cited by 1 - Related articles - All 6 versions
C Sheridan - Nature Biotechnology, 2005 - nature.com Tysabri's mechanism of action, now the focus of intense scrutiny, is thought to involve preventing
the migration of circulating inflammatory immune cells into inflamed tissues, such as the central
nervous system in the case of MS, by binding the 4 subunit of 4 1 and 4 7 integrins. But in ... Cited by 8 - Related articles - All 3 versions
C Kummer, MH Ginsberg - Biochemical pharmacology, 2006 - Elsevier The recruitment of leukocytes into tissue is a pivotal step in inflammation. α4-Integrins are adhesion
receptors on circulating leukocytes that mediate attachment to the endothelium and facilitate
their migration into the inflamed tissue. This multistep process is mediated by the ... Cited by 10 - Related articles - All 5 versions
C Sheridan - Nature reviews. Drug discovery, 2005 - ncbi.nlm.nih.gov 1: Nat Rev Drug Discov. 2005 May;4(5):357-8. Third Tysabri adverse case hits drug
class. Sheridan C. Publication Types: News. Mesh Terms: Antibodies, Monoclonal/
adverse effects*; Antibodies, Monoclonal/classification; Humans; ... Cited by 10 - Related articles - All 3 versions
MT Nguyen, S Favelyukis, AK Nguyen, D Reichart, PA … - J Biol Chem, 2007 - ASBMB Page 1. 1 A SUBPOPULATION OF MACROPHAGES INFILTRATES HYPERTROPHIC
ADIPOSE TISSUE AND IS ACTIVATED BY FFAS VIA TLR2, TLR4 AND JNK-
DEPENDENT PATHWAYS. MT Audrey Nguyen 1 , Svetlana ... Cited by 3 - Related articles - All 2 versions
J Rychly, B Nebe - Current pharmaceutical design, 2006 - ingentaconnect.com Abstract: The interaction of leukocytes with the vessel endothelium to facilitate the extravasation
into the tissue repre- sents a key process of the body's defense mechanisms. Excessive recruitment
of leukocytes into the inflamed tissue in chronic diseases like autoimmune disorders ... Cited by 13 - Related articles - BL Direct - All 4 versions
- ►nih.gov CC Féral, DM Rose, J Han, N Fox, GJ … - Journal of Clinical …, 2006 - Am Soc Clin Investig Antagonists to α4 integrin show promise for several autoimmune and inflammatory diseases
but may exhibit mechanism-based toxicities. We tested the capacity of blockade of α4 integrin
signaling to perturb functions involved in inflammation, while limiting potential adverse ... Cited by 21 - Related articles - BL Direct - All 10 versions
W Xu, W Hou, G Yao, Y Ji, M Yeh, B Sun - Biochemical and Biophysical …, 2001 - Elsevier Trichosanthin (TCS), the major effective component from Chinese herb Trichosanthes Kirilowii
Maxim, is also a potent allergen. Our previous work has shown that TCS can upregulate
interleukin-4 (IL-4) and interleukin-13 (IL-13) while inhibit interferon-γ (IFN-γ) in ... Cited by 17 - Related articles - BL Direct - All 7 versions
PDF Version - john-libbey-eurotext.fr Summary : Obesity is now considered a low-grade inflammatory disease. This relies, at least
in part, on white adipose tissue production of a variety of inflammation-related proteins, whose
expression is increased in obese subjects and reduced following weight loss. ... Related articles
M Guerre-Millo - john-libbey-eurotext.fr Résumé . L'obésité est considérée comme une maladie inflammatoire à bas bruit, au moins en
partie à cause de la production par le tissu adipeux de l'obèse d'un certain nombre de facteurs
de l'inflammation. Les facteurs inflammatoires sont produits principalement par les ... Related articles - All 2 versions
