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Scholar Results 1 - 10 of about 101 related to Levisetti: Weak proinsulin peptide–major histocompatibility complexes are targeted in autoimmun.... (0.13 sec) 

Weak proinsulin peptide–major histocompatibility complexes are targeted in autoimmune …

- diabetesjournals.org
MG Levisetti, DM Lewis, A Suri, ER Unanue - Diabetes, 2008 - Am Diabetes Assoc
RESULTS—C-peptide epitopes bound very weakly to IA g7 molecules. However,
C-peptide–reactive T-cells were induced after immunization in IA g7 –bearing
mice (NOD and B6.g7) but not in IA k –bearing mice (B10.BR and NOD.h4). T- ...
Cited by 5 - Related articles - All 5 versions

[CITATION] Crystal structure of HLA-DR2 (DRA* DRB1* 1501) complexed with a peptide from human …


KJ Smith, J Pyrdol, L Gauthier, DC Wiley, KW … - J Exp Med
Cited by 5 - Related articles

The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding …

- jimmunol.org
MG Levisetti, A Suri, SJ Petzold, ER Unanue - The Journal of Immunology, 2007 - Am Assoc Immnol
Several naturally occurring anti-insulin CD4 T cells were isolated from islet
infiltrates of NOD mice. In accordance with the results of others, these T cells
recognized the segment of the -chain from residues 9–23. Peptides ...
Cited by 10 - Related articles - All 5 versions

Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?

- nih.gov
A Suri, MG Levisetti, ER Unanue - Current opinion in immunology, 2008 - Elsevier
One seminal aspect in autoimmune diabetes is antigen presentation of beta cell
antigens by the diabetes-propensity class II histocompatibility molecules. The
binding properties of IA g7 molecules are reviewed here and an emphasis is ...
Cited by 10 - Related articles - All 10 versions

Self-peptides that bind with low affinity to the diabetes-associated IA (g7) molecule readily …


WG Ferlin, E Mougneau, S Hugues, H Appel, … - European journal of immunology, 2004 - ncbi.nlm.nih.gov
Although non-obese diabetic (NOD) mice spontaneously develop T cell
autoimmunity, it is not clear whether this phenomenon results from a defect in
tolerance to self-Ag. Furthermore, as autoimmunity has been postulated to ...
Cited by 6 - Related articles

Islet Cell Autoimmunity in NOD Mice Transgenic to HLA-DQ8 and Lacking I-Ag7


R Raju, SR Munn, C Majoribanks, CS David - Transplantation proceedings, 1998 - Elsevier
Type I diabetes is an autoimmune disease with a strong genetic predisposition as
seen by the presence of specific HLA haplotypes like HLA DR3, DR4, DQ8, and/or
DQ2.[1] However, the role of any particular HLA allele in the development ...
Cited by 10 - Related articles - BL Direct - All 8 versions

Combination of HLA-A24,-DQA1* 03, and-DR9 Contributes to Acute-Onset and Early Complete …


K Nakanishi, H Inoko - Diabetes, 2006 - Am Diabetes Assoc
To elucidate the genetic factors contributing to heterogeneity of the rate of
β-cell destruction in type 1 diabetes, we investigated the relationship between
the time course of complete β-cell loss and HLA class I and II alleles. ...
Cited by 11 - Related articles - BL Direct - All 4 versions

Predicting peptides bound to I-Ag7 class II histocompatibility molecules using a novel …


KY Chang, A Suri, ER Unanue - Proteomics, 2007 - interscience.wiley.com
The useful structural features of class II MHC molecules are rarely integrated
into T-cell epitope predictions. We propose an approach that applies a novel
expectation-maximization algorithm to align the naturally processed ...
Cited by 4 - Related articles - BL Direct - All 4 versions

Adrenalitis in the non-obese diabetic mouse


PE Beales, F Castri, A Valiani, G Rosignoli, L … - Autoimmunity, 2002 - informahealthcare.com
The non-obese diabetic (NOD) mouse is a model of spontaneous type-1 diabetes
used in the field of diabetes research. This study looked at the adrenal glands
of NOD and control mice both indirectly in vivo for hormone secretion, and ...
Cited by 4 - Related articles - BL Direct - All 6 versions

Cryptic determinants and promiscuous sequences on human acetylcholine receptor: HLA- …


R Raju, E Marietta, J Vinasco, BM Conti-Fine, … - Human immunology, 2002 - Elsevier
Experimental autoimmune myasthenia gravis can be induced in some strains of mice
and rats by immunizing with acetylcholine receptor. Also, epidemiologic studies
demonstrate an MHC linkage of myasthenia gravis in the man. In order to ...
Cited by 5 - Related articles - BL Direct - All 5 versions


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